The level of hCG in a multiple pregnancy is higher than in a single pregnancy, but the rate of increase in hCG is the same in both cases.

Vesicular drift is a rare complication of pregnancy in which the level of hCG will be significantly increased, on average 2 times higher than the average value for a given period. For example, the possible level of hCG with cystic mole for 36 days from the first day of the last menstruation can reach 200,000 mIU / ml, while with a normally developing pregnancy, hCG will be from 1,200 to 36,000 mIU / ml. nine0003

An hCG test is performed approximately 2 weeks after embryo transfer (12-14 days after transfer (dpp)). Usually the level of hCG at 14 dpo is more than 100 mIU / ml.

If the hCG level is less than 25 mIU / ml, pregnancy has not occurred. If the hCG level is more than 25, the test is repeated after 2 days, with the development of pregnancy, its level should increase. The hCG level will double approximately every 48 hours until 21 days after infusion. nine0003

Higher hCG values ​​(300-400 mIU / ml) are more likely to indicate multiple pregnancy.

In patients with ovarian hyperstimulation syndrome, hCG levels should be interpreted with caution. These patients may develop edema, which leads to thickening of the blood, which can lead to a false increase in the level of hCG, and when the blood composition is normal, to a false absence of an increase in the level of hCG. nine0003

The test for hCG is also included in the prenatal screening of the second trimester - an analysis that allows you to assess the risk of developing fetal defects.

Outside of pregnancy, hCG can be produced by the cells of some tumors (seminoma, testicular teratoma, neoplasms of the gastrointestinal tract (including pancreas, liver, colorectal cancer and stomach cancer). nine0003

With successful treatment of an hCG-producing tumor, the hCG level should decrease to normal.

In most cases, the level of hCG decreases. The half-life of hCG is 24-36 hours. The speed of reaching zero hCG values ​​depends on what exactly happened: spontaneous miscarriage, abortion, childbirth, curettage) and how high the hCG level was at the time of pregnancy loss. Doctors recommend continuing to assess hCG levels until levels are below 5 mIU/mL. If the hCG level remains high, you should consult a doctor. nine0003

The level of hCG is affected by drugs that contain hCG (Pregnil, Horagon).

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Pregnancy tests in the CIR Laboratories

In our laboratory, you can undergo a complete examination at the onset of pregnancy, take tests at any time, and in our clinics you can conclude an agreement on pregnancy management.

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All articles of the section

Early pregnancy blood test - why you need and how to donate blood

Pregnancy blood test is a procedure that is necessary to identify existing pathologies. It also allows you to determine the very presence of pregnancy, since it detects the presence in the blood of a woman of a hormone called "chorionic gonadotropin" (hCG). nine0003

In a situation where conception has not occurred, this substance is not produced in the patient's body, since its appearance is associated with the formation of the chorion. This is the tissue that occurs between the endometrium and the zygote after the attachment of a fertilized egg to the wall of the uterus.

Reasons for the test

A blood test can show the presence of pregnancy already on the sixth day after a successful conception. Whereas a standard pregnancy test in some cases can give incorrect results. Therefore, tests during pregnancy are prescribed to determine conditions such as:

• Establishment of the actual fact of conception
• Assessment of hormonal background for failures
• Pathological Pregnancy Tracker:
• Frozen - in this case, at a certain stage, the embryo stops its development
• Ectopic - in this situation, the zygote is not attached to the wall of the uterus, but in the fallopian tube

Also, a blood test shows the presence of infections, other types of dysfunctions of the body and diseases such as:

• Cytomegalovirus
• Diphtheria
• Tetanus
• Herpes
• Chlamydia
• Hepatitis
• Ureaplasmosis
• HIV
• Mycoplasmosis
• Syphilis
• Leptospirosis
• Chlamydia

Any of these diseases is a danger not only to the body of the woman herself, but also to her unborn child. Therefore, if there are deviations in the results of the blood test, the doctor sends the patient for an additional examination. nine0003

Changes in hCG during pregnancy

After the physical onset of conception, the level of hCG in the female body begins to rise, and every two to three days its concentration almost doubles. It reaches its highest level at 8-11 weeks, and then it begins to gradually decrease.

The first analysis can be taken on the 6th day of the expected delay, but the result will be more accurate on the 11-12th day. Therefore, doctors recommend undergoing a blood test two to three times (every two days later). nine0003

Controlling the level of hCG allows you to track the dynamics of pregnancy, the appearance of pathologies, etc.:

• In ectopic pregnancy, the level of the hormone practically does not increase
• If the development of the embryo has stopped, then the level of hCG drops from the moment of its death

Usually the result of the analysis is compared with a special table. In the first or second weeks, the concentration of hCG can range from 25 to 700 units, at the peak of the value it can reach 18,000–240,000 units, and at the end of the gestational age - 2,179-60,000 units.

After establishing the fact of conception, the doctor refers the patient to other blood tests:

• General
• Biochemical
• For clotting
• For hepatitis and HIV
• For TORCH infections
• For genetic pathologies
• For Rh factor and blood type (if not previously determined)
nine0005 For the content of hormones produced by the thyroid gland
• Antiphospholipid syndrome
• For STDs

Causes of deviation from the norm of the hormone hCG

Normally, after the onset of pregnancy, the level of chorionic gonadotropin should gradually increase. If it decreases, then the doctor may assume the presence of such problems as:

• In the early stages:
• Fetal death
• Probability of spontaneous termination of pregnancy
• Absence of an embryo in the ovum
• Late:
• Placental abruption

In some cases, a low level of hCG may be associated with an incorrectly calculated gestational age. Therefore, in order to determine the exact cause of low hormone levels, early pregnancy tests are usually performed, as well as several types of other examinations. nine0003

Causes of an increase in hCG levels

In the results of blood tests, the level of hCG can be seriously higher than normal for the following reasons:

• Presence of toxicosis
• More than one fetus
• Occurrence of hydatidiform mole
• Presence of genetic problems
• Complication due to diabetes mellitus

The level of human chorionic gonadotropin can be increased not only due to pregnancy, but also due to some abnormalities:

• Extremely high hCG levels due to hormonal drugs
• The presence of a malignant neoplasm in various organs (kidneys, gastrointestinal tract, uterus, lungs, etc.)
• Preservation of an unstable hormonal background as a result of an abortion

In rare cases, in the presence of serious hormonal disorders, men can also be found to have elevated levels of hCG.

Preparation for procedure

The following preparations are required before taking hCG tests for pregnant women:

• Fasting for 7-8 hours before the procedure
• Limiting the intake of any liquid a few hours before the examination

Also tell your doctor if you are taking any medications.

Statistics show that the highest concentration of hCG in the blood is observed in the first half of the day, so the doctor usually prescribes such an analysis in the morning. nine0003

If the recommendations are not followed, the study may show an unreliable result, so additional procedures will have to be carried out.

How blood sampling is performed

Blood tests for pregnant women are taken from a vein in the area located on the inside of the arm at the elbow. The procedure is as follows:

• The patient sits on a couch or chair and exposes her left or right arm
• Medic applies a tourniquet above the elbow
• After that, the woman performs several clenching of the palm into a fist
• The doctor lubricates the area of ​​the future puncture with a disinfectant
• He then inserts the needle into the vein and fills the syringe (about 10 ml of blood is needed for the test)
• After that, the tourniquet is removed, and a cotton swab is applied to the puncture area, which the patient must hold with her arm bent at the elbow (this helps to stop the release of fluid from the wound)

After these manipulations, the blood in the test tube is sent to the laboratory for analysis.

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