Pregnancy blood levels chart
HCG Levels in Pregnancy & hCG Levels Chart by Week
Human chorionic gonadotropin, or hCG for short, is often referred to as “the pregnancy hormone” because it’s present in large quantities during pregnancy. And it is, after all, the hormone that many at-home pregnancy tests are designed to detect! Find out more about what hCG is, when it’s detectable by at-home pregnancy tests, and what the typical hCG levels are for each of the early weeks of pregnancy.
What Is hCG and When Does Your Body Start Producing It?
Human chorionic gonadotropin (hCG) is known as the pregnancy hormone, as your body produces it in large amounts when you’re pregnant.
Although you can have low levels of hCG in your body at any time, the levels of this hormone tend to rise sharply early on in your pregnancy for two reasons:
About 10 days after conception, the fertilized egg attaches to the lining of your uterus and your body starts to make hCG. Over the next week or so, hCG levels will increase.
At about 4 weeks pregnant, the egg—now called an embryo—implants further into the uterus and begins to produce even more hCG, which triggers increased productions of other hormones like estrogen and progesterone.
Together, these hormones help build the lining of the uterus and send signals to the ovaries to stop releasing eggs, ultimately stopping your period.
During these early weeks of pregnancy, you may not show any outward signs of being pregnant and you may not even suspect that you’re pregnant! You may, however, experience implantation bleeding when the fertilized egg attaches to the lining of the uterus (as described above). This is normal and may resemble spotting or a light period.
When Can Pregnancy Tests Detect hCG?
Home pregnancy tests often work by detecting hCG in your urine. All of these over-the-counter pregnancy tests work a little differently, so check the instructions in or on the box. Keep in mind that hCG levels increase over time, so at-home tests are more accurate as your pregnancy progresses. Therefore, a home-pregnancy test that’s taken too early might not detect low levels of hCG and could produce a false negative, meaning the result is negative when you’re actually pregnant. If you’re wondering when to take an at-home pregnancy test, try one of the following timelines:
You might try taking a pregnancy test about three to four weeks after the first day of your last period, as this is when the levels of hCG in your urine will have increased enough to be detectable.
You could wait until around the time you miss your next period, which could be the initial clue that you may be pregnant anyway! By then, the levels of hCG are detectable.
A blood test is the most accurate way to detect hCG levels, because more of the pregnancy hormone is present in the blood than in the urine. Plus, blood tests need less of the hCG hormone to detect a pregnancy, as explained below:
Blood tests. Pregnancy blood tests can detect hCG hormone levels as low as 5 to 10 mIU/mL.
Urine tests. At-home urine tests require higher levels of hCG to detect a pregnancy, typically at least 20 mIU/mL.
If your home pregnancy test is positive, your healthcare provider may offer a blood test to check your hCG levels. The results can help your provider confirm your pregnancy and determine how far along you are.
If you’ve just found out you’re pregnant, you can get an estimate of your due date with our Due Date Calculator using either the date of conception or the date of the first day of your last menstrual period!
hCG Levels Chart by Week
The week-by-week chart below will give you an idea of how your hCG levels may rise during the first trimester, and then dip slightly during the second trimester. Keep in mind that, if you want your hCG blood test results explained in more detail, your healthcare provider is the best person to ask.
What Does It Mean if You Have High or Low hCG Levels?
It’s important to remember that every pregnancy is different, and you may have lower or higher levels of hCG hormone than what’s indicated in the week-by-week chart above. Most likely, there’s no cause for concern, but your healthcare provider will help you understand what these levels mean.
Low Levels of hCG
Low levels of hCG are normal for non-pregnant women and men. Normally, hCG levels would be less than 5 mIU/mL and less than 2 mIU/mL, respectively, for these groups. If you’re pregnant and experience low hCG levels, it’s important to look at your entire pregnancy as a whole. Your healthcare provider will consider all the factors of your pregnancy to determine why you might be experiencing lower-than-normal levels of hCG. If your provider suspects anything like an ectopic pregnancy, they may perform additional tests to rule it out.
High Levels of hCG
Likewise, high levels of the hCG hormone might not indicate anything out of the ordinary. However, a higher-than-normal level of hCG may be a sign that you’re having twins or triplets! Again, your healthcare provider will work with you to determine an appropriate course of action, if any is needed. Lower- or higher-than-normal levels of the hCG hormone during your pregnancy might not indicate anything unusual. However, it’s always a good idea to follow up with your healthcare provider as a precaution, regardless of any questions or concerns you have. Read more about other pregnancy symptoms not to ignore.
The Bottom Line
The hCG hormone plays an important role in your pregnancy, and the changing levels of this hormone are just one of many transformations your body will experience as your baby develops. Although hormonal changes can make you feel a little off from time to time during your pregnancy, try to take these as reassurance that your baby is growing, and you’re getting closer and closer to the day you finally get to meet them. In the meantime, prepare for your baby’s arrival and get rewards on all your diapers and wipes purchases with the Pampers Club app! Ready to share your pregnancy news with friends and family? Get creative pregnancy announcement ideas in the video below!
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Human chorionic gonadotropin (hCG) is a hormone normally produced by the placenta. If you are pregnant, you can detect it in your urine. Blood tests measuring hCG levels can also be used to check how well your pregnancy is progressing.
Confirming pregnancy
After you conceive (when the sperm fertilises the egg), the developing placenta begins to produce and release hCG.
It takes about 2 weeks for your hCG levels to be high enough to be detected in your urine using a home pregnancy test.
A positive home test result is almost certainly correct, but a negative result is less reliable.
If you do a pregnancy test on the first day after your missed period, and it’s negative, wait about a week. If you still think you might be pregnant, do the test again or see your doctor.
hCG blood levels by week
If your doctor needs more information about your hCG levels, they may order a blood test. Low levels of hCG may be detected in your blood around 8 to 11 days after conception. hCG levels are highest towards the end of the first trimester, then gradually decline over the rest of your pregnancy.
The average levels of hCG in a pregnant woman’s blood are:
- 3 weeks: 6 – 70 IU/L
- 4 weeks: 10 - 750 IU/L
- 5 weeks: 200 - 7,100 IU/L
- 6 weeks: 160 - 32,000 IU/L
- 7 weeks: 3,700 - 160,000 IU/L
- 8 weeks: 32,000 - 150,000 IU/L
- 9 weeks: 64,000 - 150,000 IU/L
- 10 weeks: 47,000 - 190,000 IU/L
- 12 weeks: 28,000 - 210,000 IU/L
- 14 weeks: 14,000 - 63,000 IU/L
- 15 weeks: 12,000 - 71,000 IU/L
- 16 weeks: 9,000 - 56,000 IU/L
- 16 - 29 weeks (second trimester): 1,400 - 53,000 IUL
- 29 - 41 weeks (third trimester): 940 - 60,000 IU/L
The amount of hCG in your blood can give some information about your pregnancy and the health of your baby.
- Higher than expected levels: you may have multiple pregnancies (for example, twins and triplets) or an abnormal growth in the uterus
- Your hCG levels are falling: you may be having a loss of pregnancy (miscarriage) or risk of miscarriage
- Levels that are rising more slowly than expected: you may have an ectopic pregnancy – where the fertilised egg implants in the fallopian tube
hCG levels and multiple pregnancies
One of the ways of diagnosing a multiple pregnancy is by your hCG levels. A high level may indicate you are carrying multiple babies, but it can also be caused by other factors. You will need an ultrasound to confirm that it’s twins or more.
Levels of hCG in your blood don’t provide a diagnosis of anything. They can only suggest that there are issues to look into.
If you have any concerns about your hCG levels, or wish to know more, speak to your doctor or maternity healthcare professional. You can also call Pregnancy, Birth and Baby to speak to a maternal child health nurse on 1800 882 436.
Sources:
NSW Government Health Pathology (hCG factsheet), Lab Tests Online (Human chorionic gonadotropin), UNSW Embryology (Human Chorionic Gonadotropin), Elsevier Patient Education (Human Chorionic Gonadotropin test), SydPath (hCG (human Chorionic Gonadotrophin)Learn more here about the development and quality assurance of healthdirect content.
Last reviewed: December 2020
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6 weeks pregnant is a time when embryo development is occurring rapidly and pregnant women often start experiencing pregnancy symptoms like morning sickness. Pregnancy hormone human chorionic gonadotrophin (hCG), the hormone a pregnancy test detects, is usually evident in the woman’s blood in the sixth week of pregnancy. Antenatal care should be provided at a doctor appointment for women who have not already checked their pregnancy health. Find out more about the pregnancy changes which occur this week.
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The norm of a complete blood count during pregnancy. Hemoglobin, platelets, hematocrit, erythrocytes and leukocytes during pregnancy. Clinical blood test during pregnancy. Hematological changes during pregnancy.
A normal pregnancy is characterized by significant changes in almost all organs and systems to adapt to the requirements of the fetoplacental complex, including changes in blood tests during pregnancy.
Blood test norms during pregnancy: summary of the article
- Significant hematological changes during pregnancy are physiological anemia, neutrophilia, mild thrombocytopenia, increased blood clotting factors and decreased fibrinolysis.
- By 6-12 weeks of gestation, plasma volume increases by approximately 10-15%. The fastest rate of increase in plasma volume occurs between 30 and 34 weeks of gestation, after which plasma volume changes little.
- Red blood cell count begins to increase at 8-10 weeks of gestation and by the end of pregnancy increases by 20-30% (250-450 ml) of the normal level for non-pregnant women by the end of pregnancy A significant increase in plasma volume relative to the increase in hemoglobin and red blood cell volume leads to moderate decrease in hemoglobin levels (physiological anemia of pregnancy), which is observed in healthy pregnant women.
- Pregnant women may have a slightly lower platelet count than healthy non-pregnant women.
- The neutrophil count begins to rise in the second month of pregnancy and stabilizes in the second or third trimester, at which time the white blood cell count. The absolute number of lymphocytes does not change.
- The level of some blood coagulation factors changes during pregnancy.
This article describes the hematological changes that occur during pregnancy, the most important of which are:
- Increased plasma volume and decreased hematocrit
- Physiological anemia, low hemoglobin
- Elevated white blood cells during pregnancy
- Neutrophilia
- Moderate thrombocytopenia
- Increase in procoagulant factors
- Fibrinolysis reduction
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Plasma volume
By 6-12 weeks of pregnancy, the volume of blood plasma increases by about 10-15%. The fastest rate of increase in plasma volume occurs between 30 and 34 weeks of gestation, after which plasma volume changes little. On average, plasma volume increases by 1100-1600 ml per trimester, and as a result, plasma volume during pregnancy increases to 4700-5200 ml, which is 30 to 50% higher than plasma volume in non-pregnant women.
During pregnancy, plasma renin activity tends to increase, while the level of atrial natriuretic peptide decreases slightly. This suggests that the increase in plasma volume is caused by insufficiency of the vascular system, which leads to systemic vasodilation (dilation of blood vessels throughout the body) and an increase in vascular capacity. Since it is the volume of blood plasma that initially increases, its effect on the renal and atrial receptors leads to opposite effects on the hormonal background (a decrease in plasma renin activity and an increase in natriuretic peptide). This hypothesis is also supported by the observation that an increase in sodium intake does not lead to a further increase in plasma volume.
Plasma volume immediately decreases after delivery, but rises again 2-5 days later, possibly due to increased aldosterone secretion occurring at this time. Plasma volume then gradually decreases again: 3 weeks postpartum, it is still elevated by 10-15% of the normal level for non-pregnant women, but usually returns to normal by 6 weeks postpartum.
Red blood cells during pregnancy, ESR during pregnancy
The number of red blood cells begins to increase at 8-10 weeks of gestation and by the end of pregnancy increases by 20-30% (250-450 ml) of the normal level for non-pregnant women, especially in women taking drugs iron during pregnancy. Among pregnant women who did not take iron supplements, the number of red blood cells may increase by only 15-20%. The lifespan of red blood cells decreases slightly during a normal pregnancy.
The level of erythropoietin during normal pregnancy increases by 50% and its change depends on the presence of pregnancy complications. An increase in plasma erythropoietin leads to an increase in the number of red blood cells, which partially provide for the high metabolic oxygen requirements during pregnancy.
In women not taking iron supplements, mean red cell volume decreases during pregnancy and averages 80-84 fl in the third trimester. However, in healthy pregnant women and in pregnant women with moderate iron deficiency, the average volume of erythrocytes increases by about 4 fl.
ESR increases during pregnancy, which has no diagnostic value.
Anemia in pregnancy, hemoglobin in pregnancy, hematocrit in pregnancy, low hemoglobin in pregnancy
Decreased hemoglobin in pregnancy
pregnant), which is observed in healthy pregnant women. The biggest difference between the growth rate of blood plasma volume and the number of red blood cells in the maternal circulation is formed during the end of the second, beginning of the third trimester (a decrease in hemoglobin usually occurs at 28-36 weeks of pregnancy). The hemoglobin concentration rises due to the cessation of the increase in plasma volume and the continuation of the increase in the amount of hemoglobin. Conversely, the absence of physiological anemia is a risk factor for stillbirth.Anemia in pregnancy
Defining anemia in pregnant women is difficult because it consists of pregnancy-related changes in plasma volume and red blood cell count, physiological differences in hemoglobin concentration between women and men, and the frequency of iron supplementation during pregnancy.
- The Centers for Disease Prevention and Control defined anemia as hemoglobin levels less than 110 g/L (hematocrit less than 33%) in the first and third trimesters and less than 105 g/L (hematocrit less than 32%) in the second trimester.
- WHO defined anemia in pregnancy as a decrease in hemoglobin less than 110 g/l (11 g/dl) or hematocrit less than 6.83 mmol/l or 33%. Severe anemia in pregnancy is determined by a hemoglobin level of less than 70 g/l and needs medical treatment. Very severe anemia is defined as a hemoglobin level of less than 40 g/L and is a medical emergency due to the risk of congestive heart failure.
Women with hemoglobin values below these levels are considered anemic and should undergo routine tests (CBC with peripheral blood smear evaluation, reticulocyte count, serum iron, ferritin, transferrin). If no abnormalities were detected during the examination, then hemoglobin reduced to a level of 100 g / l can be considered physiological anemia with a wide variety of factors affecting the normal level of hemoglobin in a particular person.
Chronic severe anemia is most common among women in developing countries. A decrease in maternal hemoglobin below 60 g / l leads to a decrease in the volume of amniotic fluid, vasodilation of the cerebral vessels of the fetus and a change in the heart rate of the fetus. It also increases the risk of preterm birth, miscarriage, low birth weight and stillbirth. In addition, severe anemia (hemoglobin less than 70 g/l) increases the risk of maternal death. There is no evidence that anemia increases the risk of congenital malformations of the fetus.
Severe chronic anemia is usually associated with insufficient iron stores (due to insufficient dietary intake or intestinal worm infestations), folate deficiency (due to insufficient intake and chronic hemolytic conditions such as malaria). Thus, prevention of chronic anemia and improvement of pregnancy outcome is possible with the use of nutritional supplements and the use of infection control measures.
Administering blood and packed red cell transfusions (where safe blood transfusion is available) is a reasonable aggressive treatment for severe anemia, especially if there are signs of fetal hypoxia.
Signs of physiological anemia of pregnancy disappear 6 weeks after delivery, when plasma volume returns to normal.
Iron requirement
In a singleton pregnancy, the iron requirement is 1000 mg per pregnancy: approximately 300 mg for the fetus and placenta and approximately 500 mg, if any, to increase hemoglobin. 200 mg is lost through the intestines, urine and skin. Since most women do not have an adequate supply of iron to meet their needs during pregnancy, iron is usually prescribed as part of a multivitamin, or as a separate element. In general, women taking iron supplements have a 1 g/dL higher hemoglobin concentration than women not taking iron.
Folate requirements
The daily folate requirement for non-pregnant women is 50-100 micrograms. An increase in the number of red blood cells during pregnancy leads to an increase in the need for folic acid, which is provided by increasing the dose of folic acid to 400-800 mcg per day, to prevent neural tube defects in the fetus.
Platelets during pregnancy
In most cases, the platelet count during uncomplicated pregnancy remains within the normal range for non-pregnant women, but it is also possible for pregnant women to have lower platelet counts compared to healthy non-pregnant women. The platelet count begins to rise immediately after childbirth and continues to increase for 3-4 weeks until it returns to normal values.
Thrombocytopenia in pregnancy
The most important obstetrical change in platelet physiology during pregnancy is thrombocytopenia, which may be associated with pregnancy complications (severe preeclampsia, HELLP syndrome), drug disorders (immune thrombocytopenia) or may be gestational thrombocytopenia.
Gestational or occasional thrombocytopenia is asymptomatic in the third trimester of pregnancy in patients without prior thrombocytopenia. It is not associated with maternal, fetal, or neonatal complications and resolves spontaneously after delivery. 99/l. The white blood cell count drops to the reference range for non-pregnant women by the sixth day after delivery.
Pregnant women may have a small number of myelocytes and metamyelocytes in the peripheral blood. According to some studies, there is an increase in the number of young forms of neutrophils during pregnancy. Lobe bodies (blue staining of cytoplasmic inclusions in granulocytes) are considered normal in pregnant women.
In healthy women during uncomplicated pregnancy, there is no change in the absolute number of lymphocytes and there are no significant changes in the relative number of T- and B-lymphocytes. The number of monocytes usually does not change, the number of basophils may decrease slightly, and the number of eosinophils may increase slightly.
Coagulation factors and inhibitors
During normal pregnancy, the following changes in clotting factor levels occur, leading to physiological hypercoagulation:
- Due to hormonal changes during pregnancy, the activity of total protein S antigen, free protein S antigen and protein S is reduced.
- Activated protein C resistance increases in the second and third trimesters. These changes have been identified in first-generation tests using pure blood plasma (i.e., not lacking factor V), but this test is rarely used clinically and is of only historical interest.
- Fibrinogen and factors II, VII, VIII, X, XII and XIII are increased by 20-200%.
- Von Willebrand factor rises.
- Increased activity of fibrinolysis inhibitors, TAF1, PAI-1 and PAI-2. The level of PAI-1 also increases markedly.
- Levels of antithrombin III, protein C, factor V and factor IX most often remain unchanged or increase slightly.
The end result of these changes is an increase in the tendency to thrombosis, an increase in the likelihood of venous thrombosis during pregnancy and, especially, in the postpartum period. Along with contraction of the myometrium and an increase in the level of decidual tissue factor, hypercoagulability protects the pregnant woman from excessive bleeding during labor and delivery of the placenta.
APTT remains normal during pregnancy but may decrease slightly. Prothrombin time may be shortened. Bleeding time does not change.
The timing of normalization of blood clotting activity in the postpartum period may vary depending on factors, but everything should return to normal within 6-8 weeks after delivery. The hemostasiogram should not be assessed earlier than 3 months after delivery and after lactation is completed to exclude the influence of pregnancy factors.
The influence of acquired or inherited thrombophilia factors on pregnancy is an area for research.
Postpartum period
Hematological changes associated with pregnancy return to normal 6-8 weeks after delivery. The rate and nature of the normalization of changes associated with pregnancy, specific hematological parameters are described above in the section on each parameter.
Hematological complications during pregnancy
- Iron deficiency anemia.
- Thrombocytopenia.
- Neonatal alloimmune thrombocytopenia.
- Acquired hemophilia A.
- Venous thrombosis.
- Rh and non-Rh alloimmunization. For diagnosis, an analysis is carried out for Rh antibodies and anti-group antibodies.
- A manifestation of a previously unrecognized coagulation disorder, such as von Willebrand disease, most commonly manifests in women during pregnancy and childbirth. For screening for von Willebrand disease, an assay is given to assess platelet aggregation with ristocetin.
- Aplastic anemia.
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Reticulocytes (blood level determination)
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Reticulocytes are the immediate precursors of mature erythrocytes; the indicator reflects the production of erythrocytes in the red bone marrow (assessment of erythropoiesis). The study of the number of reticulocytes is carried out in conditions that are accompanied by blood loss, anemia, after treatment with cytotoxic drugs, bone marrow transplantation.
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- Iron (Fe) (blood level determination)
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Tags: reticulocytes, anemia, blood loss, erythrocytes, transplantation, jaundice, iron deficiency anemia, red bone marrow
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