Light rash on stomach

Rash on Stomach: Symptoms, Causes, and Treatment

Skin rashes can be uncomfortable, causing patches of itchy, irritated, red, and swollen skin.

Rashes can form on any part of the skin, including the stomach.

In some cases, it’s easy to identify the cause of your stomach rash, like when you accidentally come into contact with poison oak or poison ivy.

Other times, it can be harder to know where the rash originated.

There are many possible causes of a stomach rash and many are not cause for concern.

But they all have something in common: If you’ve got a rash on your stomach, you probably want it to be gone!

In this article, I’ll tell you about some of the most common potential causes of a stomach rash.

I’ll talk about their symptoms, including serious symptoms to watch out for, and how these rashes can be treated.

I’ll also tell you when to see a doctor.

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What Causes a Rash on Your Stomach?

Not all stomach rashes are the same.

They may develop quickly, or spread over time. A rash may indicate anything from an allergic reaction to an underlying infection.

There are many possible causes of a stomach rash, which is why it’s important to speak to a provider when you’re unsure about what’s causing your symptoms.

Possible causes of a mild stomach rash include:

Pregnancy: During the third trimester of pregnancy, an itchy rash can appear in the stretch marks on the stomach. This is called pruritic urticarial papules and plaques of pregnancy, or PUPPP. This rash looks like little pink pimples or hives inside the stretch marks. The rash usually goes away within 1-2 weeks of delivering your baby. A PUPPP rash can be very itchy, but it shouldn’t cause complications for you or your baby.

Scabies: This pimple-like rash is caused by an infestation of skin mites. The human itch mite, or scabies mite, burrows into your skin and lays eggs. The resulting rash is very itchy, especially at night; the rash may also have scales. Scabies can be spread from one person to another via prolonged, skin-to-skin contact—institutions such as nursing homes and child care facilities are often the sites of scabies outbreaks. Scabies can be cured by a prescription scabicide—a product that kills the mites and their eggs.

Ringworm: This rash is not caused by a worm, as its name suggests. Ringworm is caused by a fungus, and it usually becomes a red, scaly rash in a circular—or ring-like—pattern. You can get ringworm from contact with another person who has a ringworm infection, or from an animal or object that has the fungus. Athlete’s foot and jock itch are types of ringworm. If you have it on your stomach, it’s possible that jock itch has spread up from your groin area to infect your stomach. Over-the-counter antifungal treatments can help; if they don’t, contact a doctor.

Scarlet fever: Scarlet fever is caused by the same bacteria that causes strep throat. If your child has a sore throat and a rash, they may have contracted scarlet fever. The rash usually starts on the neck, armpits, or groin, but can spread to other parts of the body, including the stomach. The rash will feel like sandpaper. Scarlet fever is more common in children, but adults can get it, too. If you or your child has scarlet fever, you’ll need antibiotics to clear the infection.

Contact dermatitis: Contact dermatitis is a type of rash that can happen when your skin comes into contact with irritants, or if you have an allergic reaction to something you’ve touched. Symptoms of contact dermatitis include redness, itching, swelling and stinging of the skin. Other times, you may experience blistering or an oozy rash, like those caused by poison ivy, poison oak, and allergic reactions. Contact dermatitis is not contagious and cannot be spread through the fluid caused by blisters.

Eczema: Eczema refers to several types of allergic skin conditions. Eczema rashes are often red, dry, and very itchy. They can appear on the face, hands, feet, inside of elbows, behind the knees, or on the stomach. Though experts don’t fully understand the connection, people with eczema are more likely to develop asthma or experience regular allergies. The severity of eczema may change over time, but it’s typically a chronic condition.

Psoriasis: The stomach is a common area for a psoriasis flare up. Psoriasis is a chronic skin disorder that causes thick pink or red patches on the skin, often covered with white or silvery scales called plaques. Psoriasis is caused by an immune disorder, and is often an inherited condition.

Impetigo: Impetigo is a highly contagious bacterial skin infection that is more commonly found on infants and young children. The main symptoms of impetigo are reddish sores that ooze. These sores usually form around the nose and mouth, though they can form elsewhere on the body, including the stomach. Antibiotic ointment or cream prescribed by a provider is required to treat the infection.

Possible causes of a more serious stomach rash include:

Allergies to food or medication: Allergic reactions to medications can happen when a substance that you’re allergic to comes in contact with your skin or enters the body through the mouth. Some allergic skin reactions can be mild, while others may be more life-threatening. If you or a loved one is experiencing a severe allergic reaction, reach out to a provider or seek emergency care immediately.

Lyme disease: Lyme disease is extremely common in the United States and is transmitted to humans through the bite of infected ticks. Symptoms include fever, headache, fatigue, and a characteristic skin rash called erythema migrans (EM). The appearance of an EM rash can vary widely. It is generally described as target-like. It usually begins as a small bump or redness at the site of the bite and then gradually expands, sometimes reaching up to 12 inches in diameter.

Kawasaki disease: Kawasaki disease (KD) is an extremely rare but serious disease that primarily affects children five years and younger. As few as 20 children in 100,000 in the United States have this condition. Though the exact cause of KD is unknown, it can cause fever for longer than five days, rash, swelling of the hands and feet, irritation and redness of the whites of the eyes, swollen lymph glands in the neck, and irritation and inflammation of the mouth, lips, and throat. Post-COVID multisystem inflammatory syndrome in children (MIS-C), is a rare condition that occurs about one month after an infection with COVID-19 and can cause similar or identical symptoms. This may be seen in children up to 17 years old.

Viral infection: Multiple viruses can also produce a rash. Viral rashes often come with additional viral symptoms, such as fever, diarrhea, runny nose, cough, or sore throat. Your healthcare provider can often recognize a viral rash based on its appearance and your other symptoms.

Symptoms of a Stomach Rash

A stomach rash can cause a wide array of symptoms, depending on the type of rash present.

Generally, a rash involves a change in the color, feeling, or texture of your skin.

Some symptoms you may experience with a stomach rash include:

Dry, red, itchy skin
Small blisters or bumps
Thick, pink or red patches on the skin
White or silvery scales on the skin
Painful patches of skin
General itchiness

Serious symptoms

Sometimes, a stomach rash can be a sign of a more serious condition.

In those cases, there may be additional symptoms present, like:

Fever
Chills
Joint pain or stiffness
Change in consciousness (including unresponsiveness or fainting)
Purple-colored rash
Shortness of breath or difficulty breathing
Sudden swelling of the face, lips, or tongue
Tightness in the throat
Symptoms that do not improve despite treatment

If you or a loved one experiences any of the above symptoms, seek emergency care as soon as possible.

What are the Treatments for a Stomach Rash?

The appropriate treatment for a skin rash depends on the cause of your symptoms.

Speak to a provider to determine which treatment option, if any, is right for you.

Prescription medications

Some skin rashes, including psoriasis and eczema, may be treated with prescription lotions, ointments, and/or oral or injectable medications.

Over-the-counter (OTC) medications

In many cases, over-the-counter (OTC) medications like hydrocortisone cream or calamine lotion can help to soothe your rash, no matter the cause.

Other OTC medications, like ibuprofen (Advil) or acetaminophen (Tylenol), may help to alleviate pain associated with your rash. Antihistamines like loratadine (Claritin), cetirizine (Zyrtec), and diphenhydramine (Benadryl) can be helpful in treating rashes and itching.

Home remedies

Before resorting to home remedies, consult with a healthcare professional to determine whether certain home remedies will make your symptoms better or worse.

If your provider says they are safe, home remedies can help soothe the discomfort and pain caused by some skin rashes.

A cool bath with baking soda, uncooked oatmeal, or colloidal oatmeal can help soothe the itching caused with chickenpox, poison ivy, and poison oak.

Stomach Rash Prevention

Not all stomach rashes are preventable.

However, there are some things you can do to prevent certain stomach rashes, including:

Practice good personal hygiene to help prevent against viral infection, including washing hands thoroughly
Avoid perfumed soaps and laundry detergents
Moisturize your skin with a fragrance-free moisturizer, especially in dry and colder temperatures
Get vaccinated whenever eligible, including the rubella and chickenpox vaccines

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When to See a Doctor

If you’ve developed a mild rash and are not experiencing any other symptoms, it’s OK to try some over-the-counter treatments and to wait a few days to see if your rash will go away on its own.

If the rash persists for a few days, spreads, becomes painful or infected, or you develop a fever, your rash may indicate a medical condition that requires treatment.

If you experience severe symptoms, or if signs of a new rash don’t go away on their own within one week, reach out to your provider.

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Frequently Asked Questions

What does a rash on the stomach mean?

There are several possible causes of a stomach rash, many of which are not cause for concern. However, if you’re unsure about what’s causing your stomach rash, seek help from a medical professional in case you need prescription treatment.

What does a stress rash look like on the stomach?

Rashes are a possible side effect of psychological stress. Rashes can include dry or sore skin, itchy patches on the skin, scaly skin, and other types of rashes.

How do you treat a rash on your stomach?

Most rashes will start to get better within a week. Depending on the type of rash you have, your provider may also recommend an over-the-counter or prescription treatment. If your rash does not improve within a week, or if you experience any severe symptoms, reach out to your provider for more information.

What does a virus rash look like?

Some viral rashes look like pink dots on the skin, while others may look lacy or like tiny blisters. Certain viral rashes are also more common in the summertime. Viral rashes often come with additional viral symptoms, such as fever, diarrhea, runny nose, cough, or sore throat.

K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.

K Health has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references.

Pruritic Urticarial Papules And Plaques Of Pregnancy. (2021).
https://www.ncbi.nlm.nih.gov/books/NBK539700/
Scabies Frequently Asked Questions (FAQs). (2020).
https://www.cdc.gov/parasites/scabies/gen_info/faqs.html
Scarlet Fever: All You Need to Know. (2021).
https://www.cdc.gov/groupastrep/diseases-public/scarlet-fever.html
Association of psychological stress with skin symptoms among medical students. (2018).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885122/
Cutaneous signs in COVID‐19 patients: A review. (2020).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273098/
Kawasaki Disease. (2020).
https://www.cdc.gov/kawasaki/about.html
Lyme Disease. (2021).
https://www.cdc.gov/lyme/index.html
Rashes. (2016).
https://medlineplus.gov/rashes.html
Rosacea. (2016).
https://medlineplus.gov/rosacea.html
Rubella. (2019).
https://www.who.int/en/news-room/fact-sheets/detail/rubella

Rash or Redness - Widespread

Is this your child's symptom?

Red or pink rash over large parts or most of the body (widespread)
Sometimes, just on hands, feet and buttocks - but same on both sides of body
Small spots, large spots or solid red skin

Causes of Widespread Rash or Redness

Viral Rash. Most rashes are part of a viral illness. Viral rashes usually have small pink spots. They occur on both sides of the chest, stomach and back. Your child may also have a fever with some diarrhea or cold symptoms. They last 2 or 3 days. More common in the summer.
Roseola. This is the most common viral rash in the first 3 years of life. (See details below).
Chickenpox. A viral rash with a distinctive pattern. (see that Care Guide)
Hand-Foot and-Mouth Disease. A viral rash with a distinctive pattern. It starts with tiny red spots and blisters on the palms and soles. (see that Care Guide)
Monkeypox. A rare viral rash that often starts on the face or genital area. It then spreads to the arms and legs. Not usually seen in children unless someone in the home has monkeypox.
Scarlet Fever. Scarlet Fever is a speckled, red rash all over. Has a sandpaper feel. Caused by the Strep bacteria. Starts on upper chest and quickly spreads to lower chest and stomach. No more serious than a Strep throat infection without a rash.
Drug Rash. Most rashes that start while taking an antibiotic are viral rashes. Only 10&percnt; turn out to be allergic drug rashes. (see details below)
Hives. Raised pink bumps with pale centers. Hives look like mosquito bites. Rashes that are bumpy and itchy are often hives. Most cases of hives are caused by a virus. Hives can also be an allergic reaction. (See that Care Guide for details)
Heat Rash. A fine pink rash caused by overheating. Mainly involves neck, chest and upper back.
Insect Bites. Insect bites cause small red bumps. Flying insects can cause many bumps on exposed skin. Non-flying insects are more likely to cause localized bumps.
Hot Tub Rash. Causes small red bumps that are painful and itchy. Mainly occurs on skin covered by a bathing suit. Rash starts 12-48 hours after being in hot tub. Caused by overgrowth of bacteria in hot tubs.
Petechiae Rash (Serious). Petechiae are purple or dark red colored tiny dots. They come from bleeding into the skin. Scattered petechiae with a fever are caused by Meningococcemia until proven otherwise. This is a life-threatening bacterial infection of the bloodstream. Peak age is 3 to 6 months old. Unlike most pink rashes, petechiae don't fade when pressed on.
Purpura Rash (Serious). Purpura means bleeding into the skin. It looks like purple or dark red larger spots. Widespread purpura is always an emergency. It can be caused by a bacterial bloodstream infection. Rocky Mountain Spotted Fever is an example.
Blister Rash (Serious). Widespread blisters on the skin are a serious sign. It can be caused by infections or drugs. Stevens Johnson Syndrome is an example.
Caution. All widespread rashes with fever need to be seen. They need to be diagnosed. Reason: some serious infections that can cause this type of rash.

Drugs and Rashes

Prescription medicines sometimes cause widespread rashes. Some are allergic, but most are not.
Non-prescription (OTC) medicines rarely cause any rashes.
Most rashes that occur while taking an OTC medicine are viral rashes.
Fever medicines (acetaminophen and ibuprofen) cause the most needless worry. Reason: most viral rashes start with a fever. Hence, the child is taking a fever medicine when the rash starts.
Drug rashes can't be diagnosed over the phone.

Roseola - A Classic Rash

Most children get Roseola between 6 months and 3 years of age.
Rash: pink, small, flat spots on the chest and stomach. Then spreads to the face.
Classic feature: 3 to 5 days of high fever without a rash or other symptoms.
The rash starts 12 to 24 hours after the fever goes away.
The rash lasts 1 to 3 days.
By the time the rash appears, the child feels fine.
Treatment: the rash is harmless. Creams or medicines are not needed.

Localized Versus Widespread Rash: How to Decide

Localized means the rash occurs on one small part of the body. Usually, the rash is just on one side of the body. An example is a rash on 1 foot. Exceptions: athlete's foot can occur on both feet. Insect bites can be scattered.
Widespread means the rash occurs on larger areas. Examples are both legs or the entire back. Widespread can also mean on most of the body surface. Widespread rashes always occur on matching (both) sides of the body. Many viral rashes are on the chest, stomach and back.
The cause of a widespread rash usually spreads through the blood stream. Examples are rashes caused by viruses, bacteria, toxins, and food or drug allergies.
The cause of a localized rash usually is just from contact with the skin. Examples are rashes caused by chemicals, allergens, insect bites, ringworm fungus, bacteria or irritants.
This is why it's important to make this distinction.

When to Call for Rash or Redness - Widespread

Call 911 Now

Purple or blood-colored spots or tiny dots with fever within the last 24 hours
Trouble breathing or swallowing
Not moving or too weak to stand
You think your child has a life-threatening emergency

Call Doctor or Seek Care Now

Bright red skin that peels off in sheets
Large blisters on skin
Bloody crusts on the lips
Taking a prescription medication within the last 3 days
Fever
Your daughter is having her period and using tampons
Your child looks or acts very sick
You think your child needs to be seen, and the problem is urgent

Contact Doctor Within 24 Hours

Widespread rash, but none of the symptoms above. Reason: all widespread rashes need to be checked by a doctor.

Seattle Children's Urgent Care Locations

If your child’s illness or injury is life-threatening, call 911.

Bellevue
Everett
Federal Way
Seattle

Care Advice for Widespread Rashes

What You Should Know About Widespread Rashes:
- Most rashes with small pink spots all over are part of a viral illness.
- This is more likely if your child has a fever. Other symptoms (like diarrhea) also point to a viral rash.
- Here is some care advice that should help until you talk with your doctor.
Non-Itchy Rash Treatment:
- If you suspect a heat rash, give a cool bath.
- Otherwise, no treatment is needed.
Itchy Rash Treatment:
- Wash the skin once with soap to remove any irritants.
- Steroid Cream. For relief of itching, use 1&percnt; hydrocortisone cream (such as Cortaid). Put it on the most itchy areas. No prescription is needed. Do this 3 times per day.
- Cool Bath. For flare-ups of itching, give your child a cool bath. Do not use soap. Do this for 10 minutes. Caution: avoid any chill. Option: Can add 2 ounces (60 mL) of baking soda per tub.
- Scratching. Try to keep your child from scratching. Cut the fingernails short. Reason: prevents a skin infection from bacteria.
- Allergy Medicine for Itching. If itching becomes severe, give an allergy medicine, such as Benadryl. No prescription is needed. Age limit: 1 and older. If needed longer than a few days, switch to a long-acting antihistamine, such as Zyrtec. Age limit: 2 and older.
Fever Medicine:
- For fevers above 102° F (39° C), give an acetaminophen product (such as Tylenol).
- Another choice is an ibuprofen product (such as Advil).
- Note: Fevers less than 102° F (39° C) are important for fighting infections.
- For all fevers: Keep your child well hydrated. Give lots of cold fluids.
Return to School:
- Most viral rashes can be spread to others (especially if a fever is present).
- If your child has a fever, avoid contact with other children. Also, avoid pregnant women until a diagnosis is made.
- For minor rashes, your child can return after the fever is gone.
- For major rashes, your child can return to school after the rash is gone. If your doctor has given medical clearance, your child can return sooner.
What to Expect:
- Most viral rashes go away within 48 hours.
Call Your Doctor If:
- You think your child needs to be seen
- Your child becomes worse

And remember, contact your doctor if your child develops any of the 'Call Your Doctor' symptoms.

Disclaimer: this health information is for educational purposes only. You, the reader, assume full responsibility for how you choose to use it.

Last Reviewed: 01/02/2023

Last Revised: 12/30/2022

symptoms and causes, what to do, prognosis

Rash on the abdomen in an adult: what could it be?

Eruptions on the abdomen can be very annoying, especially when accompanied by symptoms such as itching or burning. There can be many reasons for this ailment, we will consider the most common of them.

Types of rashes in adults

Urticaria

Reddening of the skin is accompanied by the appearance of small blisters, slightly elevated above the level of the skin, similar to those that appear after contact with nettles. nine0003

Spotted rash

Spots of indeterminate form appear on the body, usually red. They can merge with each other into small islands or be at a distance from each other. Do not rise above the surface of the skin or rise almost imperceptibly. Such a rash may disappear when the skin is stretched or pressed against it.

Papular rash

Papules are small hard blisters filled with solid contents. They feel like solid masses, look like small, firm pustules that are not filled with fluid. Their diameter can reach from 1-3 mm to 1-3 cm.

Bubble (vesicular) rash

Blisters on the skin can be filled with either clear or purulent fluid (then called pustules), tend to merge with each other [1].

Probable causes of rashes on the abdomen in adults

Skin changes on the abdomen or other parts of the body can occur for many reasons. Among the most common are allergies and some infectious diseases.

Skin diseases

This is a large group of diseases, the main manifestations of which are changes in the skin. They can be acute and chronic, infectious and non-infectious. A dermatologist deals with the treatment of skin diseases.

Skin diseases that can cause a small red rash on the abdomen include: neurodermatitis, Gibert's pink lichen, eczema, polymorphic photodermatosis, psoriasis, acne and others. Each of these pathologies has its own characteristic symptoms and features of skin manifestations [1]. nine0003

Diseases of a viral nature

Chickenpox

Chickenpox causes a rash to appear on the abdomen, back, arms, legs and face. At the beginning of the disease, these are small redness in the form of spots, which eventually transform into larger vesicles that dry out after opening. In adults, chickenpox may leave small scars [2].

Shingles

Another disease caused by the varicella-zoster virus is shingles. Before the appearance of skin changes, patients feel pain, burning and itching along the course of the nerve that was attacked by the virus. The rash is grouped into characteristic stripes along the body along the intercostal spaces. Skin lesions look the same as with chicken pox, that is, they go through stages in the form of spots, vesicles and drying of the vesicles. [3]. nine0003

Measles

The main symptoms of measles are cough, fever, redness and small spots on the face. As the disease progresses, papules may appear all over the body, but they do not require serious treatment, as they disappear on their own after a few days. As a treatment, dry ointments, for example, with zinc oxide, can be used. Remember that measles should always be diagnosed by a doctor, as it can have serious complications [4].

Allergy

We are surrounded by a huge number of allergens, so one of the most common causes of a rash on the stomach is an allergic reaction. It can be caused by chemicals used for washing, the material from which clothes are made, food, pets, cosmetics, and medicines. A rash on the abdomen caused by an allergy usually presents with redness, small spots, hives, itching, or dry, flaky skin.

Allergy treatment includes antihistamines and ointments or creams that moisturize and soothe itchy skin. To avoid such a rash in the future, it is recommended to consult an allergist and carry out allergy tests. In people prone to frequent allergic rashes, it is recommended to use hypoallergenic cosmetics, emollients specifically designed for allergic skin, and limit the consumption of highly allergenic products during daily care [5]. nine0003

Rash in diseases of the gastrointestinal tract

Skin manifestations often accompany diseases of the intestines and stomach. Violation of the absorption of vitamins, minerals and nutrients affects the condition of the skin and mucous membranes [6]. Congenital deficiencies usually appear at an early age.

In adults, the rash is associated with atopic reactions of the digestive system - such as irritable bowel syndrome, ulcerative colitis, colon polyposis, Helicobacter pylori infection (gastritis, duodenitis). There is an assumption that Helicobacter pylori can provoke the development of psoriasis [7]. nine0003

A bright rash is one of the important symptoms of typhoid fever [8].

Sexual infections

A small red rash on the abdomen is manifested in the following sexually transmitted diseases:

second stage of syphilis;
pubic pediculosis [9].

Rash on the abdomen with scabies

The scabies mite causes an itchy rash on the abdomen, the infection spreads by self-infection during scratching of the scabies in the thickness of the skin. The sooner scabies is diagnosed, the sooner you can get rid of it. It is very important not to scratch the lesions on the skin, and wash clothes and bedding at high temperatures [10]. nine0003

Infectious skin rash

Rash should not be taken as an isolated symptom. Infectious diseases also have the following signs:

fever, chills, aches, general malaise;
enlarged regional lymph nodes;
the presence of an entrance gate of infection;
history of contact with infected people;
specific changes in blood tests and biochemical analysis, characteristic of the infectious process (increased ESR, shift of the leukoformula, the appearance of C-reactive protein, etc. ). nine0084

Infections with skin manifestations include herpes, typhus, leptospirosis, rubella, hemorrhagic fevers of various origins, infectious mononucleosis, meningococcal infection, measles, typhoid fever, chickenpox, Rosenberg's erythema, paratyphoid fever, Lyme disease, pseudotuberculosis, salmonellosis , scarlet fever, enterovirus infection, Chamer's infectious erythema, erythema nodosum, etc.

Only a doctor can understand this variety. Therefore, if there are signs of an infectious disease, you should not self-medicate [11]. nine0003

Skin changes in Fabry disease

Fabry disease is a congenital disease of a genetic nature, which is accompanied by a variety of clinical manifestations. One of the characteristic symptoms of Fabry disease is angiokeratomas on the abdomen - small dark red (up to purple) rashes. They can also appear on the face, in the anus, on the fingers and toes. The elements of the rash slightly rise above the surface of the skin, inside there is a dense content.

In addition to the rash, patients complain of burning pain in the arms and legs, visual and hearing impairment, and abdominal pain. But, since the rash immediately attracts attention, this is often the first reason to see a doctor. With timely early diagnosis, the progression of Fabry disease can be slowed down with the help of modern enzyme replacement therapy [12].

Diagnosis of rashes on the abdomen

If a rash appears on the abdomen, you should consult a general practitioner or therapist who can make a diagnosis or refer you to a specialist (allergist, dermatologist, gastroenterologist, infectious disease specialist, etc.). nine0003

After questioning, examination and palpation of the elements of the rash, the doctor may prescribe additional examination methods:

complete blood count, urine, feces, biochemical blood test;
dermatoscopy;
biopsy or scraping of elements of the rash;
PCR, ELISA and other methods for the detection of specific pathogens;
endoscopic methods: FEGDS, colonoscopy, etc. ; nine0084
consultations of narrow specialists.

Allergic rash - urticaria | Symptoms

Medications, contrast agents (used in imaging studies such as computed tomography)
Signs: Allergic rash that begins within 48 hours after using the drug.

Emotional and physical stimuli (stress and anxiety, cold, exercise, skin pressure, heat, sunlight, sweating)
Signs: Allergic rash, which usually begins within seconds or minutes after contact with an irritant; an allergic rash that starts within 4 to 6 hours and affects only the area of skin where pressure has been applied, or an allergic rash that only affects the area of skin exposed to sunlight.

Food (food allergens)
Signs: Allergic rash that starts within minutes or hours of consumption. nine0003

Infections (bacterial, parasitic, viral)
Signs: Fever, chills, and fatigue. Specific infection symptoms, particularly for parasitic infections, recent travel to a developing country.

Insect bites or burns
Signs: Allergic rash that starts within seconds or minutes of an insect bite or burn.

Serum sickness
Signs: Allergic rash that begins within 7 to 10 days after an injection of a blood product (as in a transfusion), a drug derived from the blood of animals (used to treat venomous snake and spider bites). May be accompanied by fever, joint pain, swollen lymph nodes, and abdominal pain. nine0003

Contact allergens (latex, animal saliva or dander, dust, pollen or mold)
Signs: An allergic rash that begins within minutes or hours of contact.

Transfusion reactions
Signs: Allergic rash that usually starts within minutes of a blood product transfusion.

Systemic lupus erythematosus
Signs: Various symptoms depending on the autoimmune disease. With systemic lupus erythematosus, symptoms may include fever, fatigue, headache, joint pain and swelling, pain when breathing, and mouth ulcers. nine0003

Sjögren's syndrome
Signs: Dry eyes and dry mouth.

Urticarial vasculitis
Signs: An allergic rash that may be painful but not itchy. Usually lasts more than 24 hours. Does not whiten (brighten) when pressure is applied. May be accompanied by the formation of small blisters and red-violet spots (purpura).

Cancer (digestive or lung or lymphoma)
Signs: Weight loss, night sweats, abdominal pain, cough (sometimes with blood), jaundice, swollen lymph nodes, or a combination of these symptoms.

Chronic idiopathic allergic rash
Signs: Allergic rash that occurs almost daily and itching that lasts for 6 weeks with no apparent cause.

Endocrine disorders (thyroid disease or elevated progesterone)
Signs: For thyroid disorders: difficulty tolerating heat or cold, slow or fast heart rate, and shaking (tremor) or slowness.

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