Ivf fertility treatments

In vitro fertilization (IVF) - Mayo Clinic

Overview

In vitro fertilization

In vitro fertilization

During in vitro fertilization, eggs are removed from mature follicles within an ovary (A). An egg is fertilized by injecting a single sperm into the egg or mixing the egg with sperm in a petri dish (B). The fertilized egg (embryo) is transferred into the uterus (C).

In vitro fertilization (IVF) is a complex series of procedures used to help with fertility or prevent genetic problems and assist with the conception of a child.

During IVF, mature eggs are collected (retrieved) from ovaries and fertilized by sperm in a lab. Then the fertilized egg (embryo) or eggs (embryos) are transferred to a uterus. One full cycle of IVF takes about three weeks. Sometimes these steps are split into different parts and the process can take longer.

IVF is the most effective form of assisted reproductive technology. The procedure can be done using a couple's own eggs and sperm. Or IVF may involve eggs, sperm or embryos from a known or anonymous donor. In some cases, a gestational carrier — someone who has an embryo implanted in the uterus — might be used.

Your chances of having a healthy baby using IVF depend on many factors, such as your age and the cause of infertility. In addition, IVF can be time-consuming, expensive and invasive. If more than one embryo is transferred to the uterus, IVF can result in a pregnancy with more than one fetus (multiple pregnancy).

Your doctor can help you understand how IVF works, the potential risks and whether this method of treating infertility is right for you.

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Why it's done

In vitro fertilization (IVF) is a treatment for infertility or genetic problems. If IVF is performed to treat infertility, you and your partner might be able to try less-invasive treatment options before attempting IVF, including fertility drugs to increase production of eggs or intrauterine insemination — a procedure in which sperm are placed directly in the uterus near the time of ovulation.

Sometimes, IVF is offered as a primary treatment for infertility in women over age 40. IVF can also be done if you have certain health conditions. For example, IVF may be an option if you or your partner has:

• Fallopian tube damage or blockage. Fallopian tube damage or blockage makes it difficult for an egg to be fertilized or for an embryo to travel to the uterus.
• Ovulation disorders. If ovulation is infrequent or absent, fewer eggs are available for fertilization.
• Endometriosis. Endometriosis occurs when tissue similar to the lining of the uterus implants and grows outside of the uterus — often affecting the function of the ovaries, uterus and fallopian tubes.
• Uterine fibroids. Fibroids are benign tumors in the uterus. They are common in women in their 30s and 40s. Fibroids can interfere with implantation of the fertilized egg.
• Previous tubal sterilization or removal. Tubal ligation is a type of sterilization in which the fallopian tubes are cut or blocked to permanently prevent pregnancy. If you wish to conceive after tubal ligation, IVF may be an alternative to tubal ligation reversal surgery.
• Impaired sperm production or function. Below-average sperm concentration, weak movement of sperm (poor mobility), or abnormalities in sperm size and shape can make it difficult for sperm to fertilize an egg. If semen abnormalities are found, a visit to an infertility specialist might be needed to see if there are correctable problems or underlying health concerns.
• Unexplained infertility. Unexplained infertility means no cause of infertility has been found despite evaluation for common causes.
• A genetic disorder. If you or your partner is at risk of passing on a genetic disorder to your child, you may be candidates for preimplantation genetic testing — a procedure that involves IVF. After the eggs are harvested and fertilized, they're screened for certain genetic problems, although not all genetic problems can be found. Embryos that don't contain identified problems can be transferred to the uterus.

• Fertility preservation for cancer or other health conditions. If you're about to start cancer treatment — such as radiation or chemotherapy — that could harm your fertility, IVF for fertility preservation may be an option. Women can have eggs harvested from their ovaries and frozen in an unfertilized state for later use. Or the eggs can be fertilized and frozen as embryos for future use.

  Women who don't have a functional uterus or for whom pregnancy poses a serious health risk might choose IVF using another person to carry the pregnancy (gestational carrier). In this case, the woman's eggs are fertilized with sperm, but the resulting embryos are placed in the gestational carrier's uterus.

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Risks

Risks of IVF include:

• Multiple births. IVF increases the risk of multiple births if more than one embryo is transferred to your uterus. A pregnancy with multiple fetuses carries a higher risk of early labor and low birth weight than pregnancy with a single fetus does.
• Premature delivery and low birth weight. Research suggests that IVF slightly increases the risk that the baby will be born early or with a low birth weight.

• Ovarian hyperstimulation syndrome. Use of injectable fertility drugs, such as human chorionic gonadotropin (HCG), to induce ovulation can cause ovarian hyperstimulation syndrome, in which your ovaries become swollen and painful.

  Symptoms typically last a week and include mild abdominal pain, bloating, nausea, vomiting and diarrhea. If you become pregnant, however, your symptoms might last several weeks. Rarely, it's possible to develop a more severe form of ovarian hyperstimulation syndrome that can also cause rapid weight gain and shortness of breath.

• Miscarriage. The rate of miscarriage for women who conceive using IVF with fresh embryos is similar to that of women who conceive naturally — about 15% to 25% — but the rate increases with maternal age.
• Egg-retrieval procedure complications. Use of an aspirating needle to collect eggs could possibly cause bleeding, infection or damage to the bowel, bladder or a blood vessel. Risks are also associated with sedation and general anesthesia, if used.
• Ectopic pregnancy. About 2% to 5% of women who use IVF will have an ectopic pregnancy — when the fertilized egg implants outside the uterus, usually in a fallopian tube. The fertilized egg can't survive outside the uterus, and there's no way to continue the pregnancy.
• Birth defects. The age of the mother is the primary risk factor in the development of birth defects, no matter how the child is conceived. More research is needed to determine whether babies conceived using IVF might be at increased risk of certain birth defects.
• Cancer. Although some early studies suggested there may be a link between certain medications used to stimulate egg growth and the development of a specific type of ovarian tumor, more-recent studies do not support these findings. There does not appear to be a significantly increased risk of breast, endometrial, cervical or ovarian cancer after IVF.
• Stress. Use of IVF can be financially, physically and emotionally draining. Support from counselors, family and friends can help you and your partner through the ups and downs of infertility treatment.

How you prepare

The Centers for Disease Control and Prevention and the Society for Assisted Reproductive Technology provide information online about U. S. clinics' individual pregnancy and live birth rates.

A clinic's success rate depends on many factors. These include patients' ages and medical issues, as well as the clinic's treatment population and treatment approaches. Ask for detailed information about the costs associated with each step of the procedure.

Before beginning a cycle of IVF using your own eggs and sperm, you and your partner will likely need various screenings, including:

• Ovarian reserve testing. To determine the quantity and quality of your eggs, your doctor might test the concentration of follicle-stimulating hormone (FSH), estradiol (estrogen) and anti-mullerian hormone in your blood during the first few days of your menstrual cycle. Test results, often used together with an ultrasound of your ovaries, can help predict how your ovaries will respond to fertility medication.
• Semen analysis. If not done as part of your initial fertility evaluation, your doctor will conduct a semen analysis shortly before the start of an IVF treatment cycle.
• Infectious disease screening. You and your partner will both be screened for infectious diseases, including HIV.
• Practice (mock) embryo transfer. Your doctor might conduct a mock embryo transfer to determine the depth of your uterine cavity and the technique most likely to successfully place the embryos into your uterus.
• Uterine exam. Your doctor will examine the inside lining of the uterus before you start IVF. This might involve a sonohysterography — in which fluid is injected through the cervix into your uterus — and an ultrasound to create images of your uterine cavity. Or it might include a hysteroscopy — in which a thin, flexible, lighted telescope (hysteroscope) is inserted through your vagina and cervix into your uterus.

Before beginning a cycle of IVF, consider important questions, including:

• How many embryos will be transferred? The number of embryos transferred is typically based on age and number of eggs retrieved. Since the rate of implantation is lower for older women, more embryos are usually transferred — except for women using donor eggs or genetically tested embryos.

  Most doctors follow specific guidelines to prevent a higher order multiple pregnancy, such as triplets or more. In some countries, legislation limits the number of embryos that can be transferred. Make sure you and your doctor agree on the number of embryos that will be transferred before the transfer procedure.

• What will you do with any extra embryos? Extra embryos can be frozen and stored for future use for several years. Not all embryos will survive the freezing and thawing process, although most will.

  Having frozen embryos can make future cycles of IVF less expensive and less invasive. Or, you might be able to donate unused frozen embryos to another couple or a research facility. You might also choose to discard unused embryos.

• How will you handle a multiple pregnancy? If more than one embryo is transferred to your uterus, IVF can result in a multiple pregnancy — which poses health risks for you and your babies. In some cases, fetal reduction can be used to help a woman deliver fewer babies with lower health risks. Pursuing fetal reduction, however, is a major decision with ethical, emotional and psychological consequences.
• Have you considered the potential complications associated with using donor eggs, sperm or embryos, or a gestational carrier? A trained counselor with expertise in donor issues can help you understand the concerns, such as the legal rights of the donor. You may also need an attorney to file court papers to help you become legal parents of an implanted embryo.

What you can expect

IVF involves several steps — ovarian stimulation, egg retrieval, sperm retrieval, fertilization and embryo transfer. One cycle of IVF can take about two to three weeks. More than one cycle may be needed.

Ovulation induction

The start of an IVF cycle begins by using synthetic hormones to stimulate the ovaries to produce multiple eggs — rather than the single egg that typically develops each month. Multiple eggs are needed because some eggs won't fertilize or develop normally after fertilization.

Several different medications may be used, such as:

• Medications for ovarian stimulation. To stimulate your ovaries, you might receive an injectable medication containing a follicle-stimulating hormone (FSH), a luteinizing hormone (LH) or a combination of both. These medications stimulate more than one egg to develop at a time.
• Medications for oocyte maturation. When the follicles are ready for egg retrieval — generally after eight to 14 days — you will take human chorionic gonadotropin (HCG) or other medications to help the eggs mature.
• Medications to prevent premature ovulation. These medications prevent your body from releasing the developing eggs too soon.
• Medications to prepare the lining of your uterus. On the day of egg retrieval or at the time of embryo transfer, your doctor might recommend that you begin taking progesterone supplements to make the lining of your uterus more receptive to implantation.

Your doctor will work with you to determine which medications to use and when to use them.

Typically, you'll need one to two weeks of ovarian stimulation before your eggs are ready for retrieval. To determine when the eggs are ready for collection, you may have:

• Vaginal ultrasound, an imaging exam of your ovaries to monitor the development of follicles — fluid-filled ovarian sacs where eggs mature
• Blood tests, to measure your response to ovarian stimulation medications — estrogen levels typically increase as follicles develop, and progesterone levels remain low until after ovulation

Sometimes IVF cycles need to be canceled before egg retrieval for one of these reasons:

• Inadequate number of follicles developing
• Premature ovulation
• Too many follicles developing, creating a risk of ovarian hyperstimulation syndrome
• Other medical issues

If your cycle is canceled, your doctor might recommend changing medications or their doses to promote a better response during future IVF cycles. Or you may be advised that you need an egg donor.

Egg retrieval

Egg retrieval can be done in your doctor's office or a clinic 34 to 36 hours after the final injection and before ovulation.

• During egg retrieval, you'll be sedated and given pain medication.
• Transvaginal ultrasound aspiration is the usual retrieval method. An ultrasound probe is inserted into your vagina to identify follicles. Then a thin needle is inserted into an ultrasound guide to go through the vagina and into the follicles to retrieve the eggs.
• If your ovaries aren't accessible through transvaginal ultrasound, an abdominal ultrasound may be used to guide the needle.
• The eggs are removed from the follicles through a needle connected to a suction device. Multiple eggs can be removed in about 20 minutes.
• After egg retrieval, you may experience cramping and feelings of fullness or pressure.
• Mature eggs are placed in a nutritive liquid (culture medium) and incubated. Eggs that appear healthy and mature will be mixed with sperm to attempt to create embryos. However, not all eggs may be successfully fertilized.

Sperm retrieval

If you're using your partner's sperm, a semen sample needs to be provided at your doctor's office or clinic the morning of egg retrieval. Typically, the semen sample is collected through masturbation. Other methods, such as testicular aspiration — the use of a needle or surgical procedure to extract sperm directly from the testicle — are sometimes required. Donor sperm also can be used. Sperm are separated from the semen fluid in the lab.

Fertilization

Fertilization can be attempted using two common methods:

• Conventional insemination. During conventional insemination, healthy sperm and mature eggs are mixed and incubated overnight.
• Intracytoplasmic sperm injection (ICSI). In ICSI, a single healthy sperm is injected directly into each mature egg. ICSI is often used when semen quality or number is a problem or if fertilization attempts during prior IVF cycles failed.

In certain situations, your doctor may recommend other procedures before embryo transfer.

• Assisted hatching. About five to six days after fertilization, an embryo "hatches" from its surrounding membrane (zona pellucida), allowing it to implant into the lining of the uterus. If you're an older woman, or if you have had multiple failed IVF attempts, your doctor might recommend assisted hatching — a technique in which a hole is made in the zona pellucida just before transfer to help the embryo hatch and implant. Assisted hatching is also useful for eggs or embryos that have been previously frozen as the process can harden the zona pellucida.
• Preimplantation genetic testing. Embryos are allowed to develop in the incubator until they reach a stage where a small sample can be removed and tested for specific genetic diseases or the correct number of chromosomes, typically after five to six days of development. Embryos that don't contain affected genes or chromosomes can be transferred to your uterus. While preimplantation genetic testing can reduce the likelihood that a parent will pass on a genetic problem, it can't eliminate the risk. Prenatal testing may still be recommended.

Embryo transfer

Egg-retrieval technique

Egg-retrieval technique

Typically, transvaginal ultrasound aspiration is used to retrieve eggs. During this procedure, an ultrasound probe is inserted into your vagina to identify follicles, and a needle is guided through the vagina and into the follicles. The eggs are removed from the follicles through the needle, which is connected to a suction device.

ICSI

ICSI

In intracytoplasmic sperm injection (ICSI), a single healthy sperm is injected directly into each mature egg. ICSI is often used when semen quality or number is a problem or if fertilization attempts during prior in vitro fertilization cycles failed.

Blastocyst

Blastocyst

Three days after fertilization, a normally developing embryo will contain about six to 10 cells. By the fifth or sixth day, the fertilized egg is known as a blastocyst — a rapidly dividing ball of cells. The inner group of cells will become the embryo. The outer group will become the cells that nourish and protect it.

Embryo transfer is done at your doctor's office or a clinic and usually takes place two to five days after egg retrieval.

• You might be given a mild sedative. The procedure is usually painless, although you might experience mild cramping.
• The doctor will insert a long, thin, flexible tube called a catheter into your vagina, through your cervix and into your uterus.
• A syringe containing one or more embryos suspended in a small amount of fluid is attached to the end of the catheter.
• Using the syringe, the doctor places the embryo or embryos into your uterus.

If successful, an embryo will implant in the lining of your uterus about six to 10 days after egg retrieval.

After the procedure

After the embryo transfer, you can resume your usual daily activities. However, your ovaries may still be enlarged. Consider avoiding vigorous activity, which could cause discomfort.

Typical side effects include:

• Passing a small amount of clear or bloody fluid shortly after the procedure — due to the swabbing of the cervix before the embryo transfer
• Breast tenderness due to high estrogen levels
• Mild bloating
• Mild cramping
• Constipation

If you develop moderate or severe pain after the embryo transfer, contact your doctor. He or she will evaluate you for complications such as infection, twisting of an ovary (ovarian torsion) and severe ovarian hyperstimulation syndrome.

Results

About 12 days to two weeks after egg retrieval, your doctor will test a sample of your blood to detect whether you're pregnant.

• If you're pregnant, your doctor will refer you to an obstetrician or other pregnancy specialist for prenatal care.
• If you're not pregnant, you'll stop taking progesterone and likely get your period within a week. If you don't get your period or you have unusual bleeding, contact your doctor. If you're interested in attempting another cycle of in vitro fertilization (IVF), your doctor might suggest steps you can take to improve your chances of getting pregnant through IVF.

The chances of giving birth to a healthy baby after using IVF depend on various factors, including:

• Maternal age. The younger you are, the more likely you are to get pregnant and give birth to a healthy baby using your own eggs during IVF. Women age 41 and older are often counseled to consider using donor eggs during IVF to increase the chances of success.
• Embryo status. Transfer of embryos that are more developed is associated with higher pregnancy rates compared with less-developed embryos (day two or three). However, not all embryos survive the development process. Talk with your doctor or other care provider about your specific situation.
• Reproductive history. Women who've previously given birth are more likely to be able to get pregnant using IVF than are women who've never given birth. Success rates are lower for women who've previously used IVF multiple times but didn't get pregnant.
• Cause of infertility. Having a normal supply of eggs increases your chances of being able to get pregnant using IVF. Women who have severe endometriosis are less likely to be able to get pregnant using IVF than are women who have unexplained infertility.
• Lifestyle factors. Women who smoke typically have fewer eggs retrieved during IVF and may miscarry more often. Smoking can lower a woman's chance of success using IVF by 50%. Obesity can decrease your chances of getting pregnant and having a baby. Use of alcohol, recreational drugs, excessive caffeine and certain medications also can be harmful.

Talk with your doctor about any factors that apply to you and how they may affect your chances of a successful pregnancy.

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What Is In-Vitro-Fertilization (IVF)?

In This Section

• Fertility Treatments
• What is IVF?

• What is IUI?

In vitro fertilization (IVF) helps with fertilization, embryo development, and implantation, so you can get pregnant.

How does IVF work?

IVF stands for in vitro fertilization. It’s one of the more widely known types of assisted reproductive technology (ART).  IVF works by using a combination of medicines and surgical procedures to help sperm fertilize an egg, and help the fertilized egg implant in your uterus.

First, you take medication that makes several of your eggs mature and ready for fertilization. Then the doctor takes the eggs out of your body and mixes them with sperm in a lab, to help the sperm fertilize the eggs. Then they put 1 or more fertilized eggs (embryos) directly into your uterus. Pregnancy happens if any of the embryos implant in the lining of your uterus.

IVF has many steps, and it takes several months to complete the whole process. It sometimes works on the first try, but many people need more than 1 round of IVF to get pregnant. IVF definitely increases your chances of pregnancy if you’re having fertility problems, but there’s no guarantee — everyone’s body is different and IVF won’t work for everyone.

What’s the IVF process?

The first step in IVF is taking fertility medications for several months to help your ovaries produce several eggs that are mature and ready for fertilization. This is called ovulation induction. You may get regular ultrasounds or blood tests to measure your hormone levels and keep track of your egg production.

Once your ovaries have produced enough mature eggs, your doctor removes the eggs from your body (this is called egg retrieval). Egg retrieval is a minor surgical procedure that’s done at your doctor’s office or at a fertility clinic.

You’ll get medicine to help you be relaxed and comfortable during the procedure. Using an ultrasound to see inside your body, the doctor puts a thin, hollow tube through your vagina and into the ovary and follicles that hold your eggs. The needle is connected to a suction device that gently pulls the eggs out of each follicle.

In a lab, your eggs are mixed with sperm cells from your partner or a donor — this is called insemination. The eggs and sperm are stored together in a special container, and fertilization happens. For sperm that have lower motility (don’t swim as well), they may be injected directly into the eggs to promote fertilization. As the cells in the fertilized eggs divide and become embryos, people who work at the lab monitor the progress.

About 3-5 days after the egg retrieval, 1 or more embryos are put into your uterus (this is called embryo transfer).  The doctor slides a thin tube through your cervix into your uterus, and inserts the embryo directly into your uterus through the tube.

Pregnancy happens if any of the embryos attach to the lining of your uterus.  Embryo transfer is done at your doctor’s office or at a fertility clinic, and it’s usually not painful.

Plan on resting for the rest of the day after your embryo transfer. You can go back to your normal activities the next day. You may also take pills or get daily shots of a hormone called progesterone for the first 8-10 weeks after the embryo transfer. The hormones make it easier for the embryo to survive in your uterus.

What are the side effects of IVF?

Like all medications and medical procedures, IVF has some risks and possible side effects. These include:

Your doctor can talk with you about any questions or concerns you have about IVF risks and side effects.

IVF can also be difficult emotionally, both for the person having the procedures and for their partner and/or family. Many people doing IVF treatments struggle with depression and anxiety throughout the process.

Talking with people who’ve been through fertility struggles and IVF can be really helpful if you’re feeling overwhelmed or discouraged. Online and in-person communities are also good places to meet people who understand what you’re going through and can offer advice and support. Counselors and therapists can also be sources of comfort.

You can find more information on support groups and coping with the stress of fertility treatments at RESOLVE: The National Infertility Association. Your doctor, fertility specialist, or local Planned Parenthood health center may also be able to offer you other resources and tips on finding therapists or support groups in your area.

How much does IVF cost?

IVF tends to be pretty expensive. A few states have laws that say health insurance companies must cover some or all of the costs of infertility treatment if you meet certain requirements. But many insurance plans don’t offer any fertility treatment coverage at all.

You can find more information about insurance coverage of IVF and other fertility treatments at The National Infertility Association.

The fees for 1 cycle of IVF include medicines, procedures, anesthesia, ultrasounds, blood tests, lab work, and embryo storage. The exact cost of a single IVF cycle varies, but it can be up to $15,000 or more.

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After the first attempt, I became a mother

Anonymous

I turned to Elena Viktorovna to do IVF. She performed the procedure and after the first attempt I became a mother! Elena Viktorovna is a very competent, educated reproductologist. She gets the most out of it and helps us solve the problem with her individual approach to solving the problem. Shirinkina Elena Viktorovna is a competent reproductive specialist.

This is a chance for many couples to become parents!

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September 01, 2022

We contacted Svetlana Viktorovna Filimonova in 2016. And in 2017, thanks to Svetlana Viktorovna, we had our first long-awaited baby. In 2020, we again turned to Svetlana Viktorovna for twins. And in 2022, royal twins were born. Svetlana Viktorovna is a very responsive doctor. Attentive, reliable and just a wonderful person. Both pregnancies Svetlana Viktorovna was in touch. Advised and supported. Thanks to Svetlana Viktorovna, I experienced this incredible feeling and I wish every woman who dreams of becoming a mother to experience it. To all my friends who have problems conceiving and carrying a pregnancy, I recommend Svetlana Viktorovna! I am very proud that there are such doctors in our country. This is a chance for many couples to become parents!

A friend for life!

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02 December 2021

Elena Viktorovna Shirinkina is not just a doctor. For us, she is a friend for life! Elena Viktorovna gave us happiness and a new world! We have become different. I thank the clinic for such a wonderful doctor. It is very important to be on the same wavelength and live through all the stages together. I have never seen such support. We love, appreciate our Elena Viktorovna Shirinkina.

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01 December 2021

We would like to express our deep gratitude to Ekaterina Sergeevna Kozlovskaya for our son. We were born on 10/28/2021. Thank you very much. I couldn't believe it was real until the very end!

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Anonymous

October 30, 2021

We were born on August 30, 2021. Weight 3450, height 49 cm. Today we are already 2 months old. Thank you very much for our baby Ekaterina Sergeevna Kozlovskaya. She helped us become happy parents.

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October 28, 2021

We did IVF with Svetlana Viktorovna Filimonova, as a result of which our son was born, on the first try! The doctor is very responsive, attentive, answers all questions, explains everything. He does all the procedures carefully, he will show and tell everything on the ultrasound, he will always cheer you up!

The best clinic and the best staff

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June 15, 2020

The best doctor! Thanks to Ekaterina Sergeevna and Olga Yurievna for our beautiful daughter. Our happiness has been waiting for so many years, Ekaterina Sergeevna helped us become parents of a beautiful princess in less than a year. The best clinic and the best staff

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Anonymous

December 02, 2019

Kozlovskaya Ekaterina Sergeevna is a true professional.

Thanks to her sensitive attitude and competent help, my husband and I became happy parents.

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Anonymous

September 27, 2019

Kozlovskaya Ekaterina Sergeevna - Doctor with a capital letter. Experience and competence at the highest level! Doesn't order any extra tests. Communicates remotely, guides his "eco" girls for the first trimester. I have never met a better doctor. God bless her! Successful IVF 1 time. Thanks for the daughter. :)

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Anonymous

September 25, 2019

I visited Dr. Filimonova more than once and have known her for about two years. I choose this particular specialist because I am attracted by her friendliness and sociability. Svetlana Viktorovna makes contact and inspires confidence. At the moment, I am undergoing examination with the help of equipment, and also taking tests. Therefore, after that I need to come back for a second appointment with the doctor, since I am not taking medication yet. Of course, I had previously been treated by this doctor, and everything was fine, it turned out to be effective. In general, they usually take me on time, I don’t wait for hours. The appointment itself takes an average of 15-20 minutes. Naturally, this time is enough for me, I ask certain questions and get proper answers. If during the conversation the doctor uses complex medical terms, he explains their meaning. I think that the cost of taking this specialist is quite acceptable. In my opinion, Svetlana Viktorovna can be recommended to her friends and acquaintances, if necessary.

1000 thanks to Ekaterina Sergeevna Kozlovskaya

Anna Ts.

01 September 2019

After 2.5 years of unsuccessful attempts to get pregnant, thanks to a group at the Perm forum, I decided to apply for IVF under CHI (for some reason, not a single doctor told us about this possibility). We were put in a queue, and six months later I received a quota. By this time, I have visited all Perm clinics that provide such a service, I saw and talked with doctors, read reviews and recommendations on the Internet. I understood that 90% success (another 9% from the embryologist and 1% luck). I was lucky - I found "my doctor" who understands, sincerely wants to help and is ready to answer any questions day and night. They became Ekaterina Sergeevna Kozlovskaya. With her, we went through the first fresh protocol (hCG <1), cryoprotocol (hCG on day 10 74, 12-72 and 14-40), and the second fresh IVF protocol for CHI in November 2018. We carefully prepared for it: hysteroscopy, recommendations of an endocrinologist and a hematologist. And after 4 years of our planning, the result was positive! On my husband's birthday - December 7, I gave him a sheet with the result of hCG 132! My pregnancy proceeded without any complications. But I was ready for toxicosis, and for gluttony, and for the rejection of smells ... When you wait SO long for the fulfillment of your cherished dream, you are ready for anything for it!

40 weeks flew by in one breath. On August 22, our long-awaited son was born. Unfortunately, childbirth was the complete opposite of pregnancy. After long agony of contractions, a puncture of the bladder and attempts, the baby's pulse began to fall. And the doctors decided to urgently do a Cesarean. Saved my son! He was born with a weight of 3.45 kg and a height of 53 cm, absolutely healthy! This little lump lay on my chest while I was operated on and warmed me with its warmth. Then I finally realized that I had become a mother! A cherished dream has come true! And I owe this happiness to my fertility doctor - Ekaterina Sergeevna. I want to thank her for everything she did to make my dream come true, but I'm afraid that even 1000 thanks will not be enough.

Thank you so much for our son!

Thanks to Olga Vladimirovna

Polina

August 04, 2019

I want to express my deep gratitude and gratitude for our miracle and treasure, which was born to your magical hands! Thank you for your professionalism, patience and sensitivity. Special thanks to the embryologists.

Gratitude and gratitude to Olga Vladimirovna Fotina

Yana F.

July 30, 2019

We express our immense gratitude and appreciation for the long-term support of our family to Olga Vladimirovna Fotina. On June 19, I had an appointment with this wonderful doctor, a true professional in his field. Now, thanks to you and your wonderful team, we are a real Family!

Thanks to Olga Vladimirovna Fotina

Anna

July 30, 2019

Thank you so much for our angels! Thank you for your confidence and support!

Thanks to Olga Vladimirovna and Larisa Ivanovna

Anastasia

July 30, 2019

Our little boys are growing up, one is a copy of mom, the second is a copy of dad, Olga Vladimirovna and Laisa Ivanovna conjured wonderfully! Thank you for your golden hands.

Thank you so much for your work and for my daughter!

Alina K.

July 30, 2019

Good afternoon! 06/06/2019 I became a mother for the first time. Thank you so much for your work and for my daughter! I wish you success in your business, because not everyone is given such happiness to people!

Thank you for happiness

Lidia Ivanovna P.

July 29, 2019

Thank you very much, Olga Vladimirovna and Larisa Ivanovna Zaitseva, for the happiness that you gave us.

Thanks to Olga Vladimirovna Fotina

Alexandra A.

July 16, 2019

Good day! I want to express my deep gratitude to Olga Vladimirovna Fotina for her support, professionalism and positive attitude. And also grateful to all the medical staff who took part in all our attempts. I went through the IVF procedure in your clinic, we succeeded on the 4th attempt, and now I am the happiest mother in the whole world, my daughter, my treasure, was born. We are already 3 months and 3 weeks old.

Elena Viktorovna very good doctor

Anonymous

July 03, 2019

In my opinion, this is a very good doctor! Elena Viktorovna seemed kind and attentive to me. The specialist looked at all the tests and even gave some hope. The doctor made recommendations, said that you need to take tests, undergo a colposcopy and then go back to her. It was the first time at the reproductologist, I decided to apply myself. I felt comfortable and good. Reception started on time. The doctor asked me about my complaints, symptoms, what diseases I had before. I also had an examination. There was no rush at the reception. Shirinkina E.V. I liked it and I will go to her again! I think that the specialist was interested in my question, was not distracted by anything. I was completely free, calm and not shy!

Review of the doctor Isaeva Nadezhda Vladimirovna

Anonymous

June 27, 2019

The doctor answered all the questions that I had, Nadezhda Vladimirovna explained everything clearly. I felt comfortable, the doctor more or less disposes to communication. Everything was fine. I turned to a specialist for advice. She did not give appointments, she only sent me to undergo an examination. There is no need to re-apply. I was referred to a reproductologist, I made an appointment with the nearest available doctor. The specialist did not make a diagnosis, the question was different.

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March 03, 2023

Opening hours of the reproductive clinic on public holidays

Lovely women! Congratulations on the upcoming International Women's Day!
We would like to inform you about the work schedule of the "Philosophy of Life" reproduction clinic during the holidays

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Dear customers! Please note the changes in the schedule of the clinic from 23 to 25 February!

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01 October 2022

Special prices for freezing and storing semen

Offer valid until November 30

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answers to frequently asked questions

• General questions
• About donation
• Legal issues

Performed in an IVF clinic for HIV-infected patients?

ART in HIV-infected patients is performed in stage 3 (subclinical) or in stage 4, provided that the remission period lasts at least 6 months. It is necessary to have a certificate from the AIDS center with information about the stage and phase of HIV infection, the results of laboratory tests over the past 3 months (lymphocyte count (CD4), viral load). It is also necessary to have a conclusion from the AIDS Center on the possibility of RT at the present time.

What documents do I need to bring to the initial appointment?

All examinations and test results for the current year must be brought to the initial consultation.

Is sick leave issued?

Sick leave is issued from the 1st day of the start of the IVF program. The decision to issue a sick leave is made individually, provided that the general well-being in the IVF program is not impaired. If the working conditions and working hours allow you to organize a visit to the clinic, you can not open a sick leave sheet.

Possible fears and real consequences of egg donation for the donor

Many women who think about this procedure have the question of whether it is dangerous to be an egg donor. In most cases, there are no consequences for the oocyte donor at all. Speaking of possible concerns, the most common and typical of them are:

• Negative effects of hormones used to stimulate ovulation. Such hormone therapy takes about 2 weeks. For such a short period of time, hormonal drugs cannot affect a healthy female body.
• Weight gain. This fear is also based on the use of hormonal drugs. In some cases, weight gain can indeed be observed, but it will remain insignificant due to the short duration of therapy.
• Negative effect on own fertility. Egg donation does not affect the ability of a healthy woman with a normal ovarian reserve to have children of her own.
• Among the side effects of the procedure that can occur in women, doctors call headache, swelling, mood swings, minor bruising. All of these symptoms are extremely rare and completely reversible.

How soon after giving birth can I participate in the donation program?

After you stop breastfeeding, you must wait at least 3-4 months before starting the program. The hormonal cycle must be fully restored.

Is the ovarian puncture procedure painful?

Absolutely not. Egg retrieval is carried out under intravenous anesthesia under sterile conditions, and it lasts no more than 10 minutes. With a thin needle, a liquid is taken from the ovary, which contains mature eggs. There may be a slight pulling pain in the lower abdomen, as in the first days of menstruation.

How many times can I donate?

According to the norms of the Ministry of Health - no more than 6-8 times. Re-entry is possible every 3 months.

Can a breastfeeding woman be an egg donor?

No, it cannot, because a nursing mother, firstly, can be further weakened after her birth and breastfeeding.

Secondly, she simply may not have her own eggs at a given time. Since immediately after childbirth, the endocrine system of a woman, and in particular the pituitary gland (an endocrine gland, or the so-called conductor of the endocrine system), begins to intensively produce the hormone prolactin. As you know, this hormone stimulates the production of milk in the mammary glands and at the same time suppresses the cyclic production of hormones in the ovary, thereby preventing the processes of egg maturation and ovulation (the release of an egg from the ovary). Therefore, menstruation does not occur.

Thirdly, even if a breastfeeding woman is suitable for egg donation in all other respects, she will be stimulated with hormonal preparations for egg maturation. This is just something that can be harmful to her baby, whom she is breastfeeding. Also, such stimulation can be a serious stress for the woman herself.

Wait until lactation stops.

Who can be a sperm donor?

In accordance with paragraph 62 of the Order of the Ministry of Health of the Russian Federation dated August 30, 2012 No. 107n “on the procedure for the use of assisted reproductive technologies, contraindications and restrictions on their use”, sperm donors are eligible to be men aged 18 to 35 years, physically and mentally healthy, passed medical genetic examination. Sperm donors can be both non-anonymous and anonymous donors.

Who can donate oocytes?

By virtue of paragraph 54 of the Order of the Ministry of Health of the Russian Federation dated August 30, 2012 No. 107n “on the procedure for the use of assisted reproductive technologies, contraindications and restrictions on their use”, women aged 18 to 35 years old, physically and mentally, have the right to be oocyte donors healthy, passed medical-genetic examination. Oocyte donors can be both non-anonymous and anonymous donors.

What documents must be submitted to the registry office when registering a child born through surrogacy?

In accordance with Article 16 of the Federal Law of November 15, 1997 N 143-FZ

"On acts of civil status" during state registration of the birth of a child at the request of the spouses who agreed to implant the embryo to another woman for the purpose of carrying it, simultaneously with the document , confirming the fact of the birth of a child, a document issued by a medical organization and confirming the fact of obtaining the consent of the woman who gave birth to the child (surrogate mother) must be submitted to record the indicated spouses as the parents of the child.

Who can be a surrogate mother?

According to paragraph 10 of Article 55 of Federal Law N 323-FZ, a surrogate mother can be a woman between the ages of twenty and thirty-five, who has at least one healthy child of her own, who has received a medical certificate of a satisfactory state of health, who has given written informed voluntary consent to medical intervention. A woman who is married, registered in the manner prescribed by the legislation of the Russian Federation, can be a surrogate mother only with the written consent of her husband. A surrogate mother cannot be an egg donor at the same time.

Can a single woman in Russia use the services of a surrogate mother?

Yes, by virtue of paragraph 9 of Article 55 of Federal Law N 323-FZ, a single woman can use the services of a surrogate mother.

Can a single man in Russia use the services of a surrogate mother?

In accordance with paragraph 9 of Article 55 of the Federal Law of November 21, 2011 N 323-FZ "On the Fundamentals of Protecting the Health of Citizens in the Russian Federation" (hereinafter - Federal Law N 323-FZ), surrogate motherhood is the bearing and birth of a child (including including premature births) under an agreement concluded between a surrogate mother (a woman carrying a fetus after the transfer of a donor embryo) and potential parents whose germ cells were used for fertilization, or a single woman for whom the bearing and birth of a child is impossible for medical reasons.

Thus, at present, only a couple or a single woman can use the services of a surrogate mother in Russia.

Do you have any questions?

Call:

Email:

[email protected]

NGC clinic - infertility treatment and IVF in St. Petersburg

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St. Petersburg,
Petrovsky Prospekt 2, building 3

Mon-Sat: 8:30 am - 8:30 pm
Sun: 10:00 am - 5:00 pm

+7 812 445-85-81

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+7 (812) 445-85-81

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Infertility treatment

IVF, ICSI, AI, donor programs, delayed motherhood, IVM and others

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Donor biomaterial bank

The largest cryobank of oocytes, sperm, embryos. More than 600 donors

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Reproduction

Genetics

Reproductive health

Treatment of infertility

Modern

Ultra-abundant air purification and ventilation system, cryoquives

Cultivation

Observation of the Embrian 24. Free for all patients

Monitoring

Automated system for monitoring the movement of patient biomaterial

Donor programs

Unique electronic catalog of donors, personified selection

Urology

Conservative and microsurgical treatment of male infertility

Pregnancy

Intensively experience after IVF, Expert equipment

In the NGC retroduction clinic of the NGC. sciences: world experience in the treatment of female and male infertility using ART methods, the latest developments in the field of prenatal diagnosis and genetics.

Every day we strive to improve the efficiency of IVF protocols. To do this, we continuously optimize all processes, introduce new services and technologies.

We have the largest cryobank in Russia, our own genetics laboratory, we have the most intensive experience in conducting PGT-A embryos, we were among the first to introduce the Time-Lapse and RI Witness systems into the work.

IVF cycles performed
annually

Effectiveness
ART programs

Sperm donors

Anna

February 1, 2023

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Take the first step towards happiness!

Our employees stood at the origins of the development of reproductive medicine in Russia and are known throughout the world as high-level professionals!

Our team

Specialists of the reproduction clinic

• Kornilov

  
  Nikolai
  Valeryevich

  Medical adviser
  Reproductologist

• 127 Andrey
  Adolfovich

  Medical Director
  Reproductologist, Candidate of Medical Sciences

• Zabelkina

  
  Olga

• Kamenetsky

  
  Boris
  Aleksandrovich

  Leading reproductive specialist, PhD

• Kurilo

  
  Alexey
  Olegovich

  Leading Reproductologist

• Denisova

  
  Valentina
  Mikhailovna

  Reproductologist, PhD Ph.

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