Embryo brain development

When Does a Fetus Develop a Brain?

Pregnancy is an exciting time full of rapid change and development for both you and your baby. While the growth happening on the outside is clear to everyone (hello, growing belly!), it’s the development we can’t see that is truly fascinating.

Your fetus will begin the process of developing a brain around week 5, but it isn’t until week 6 or 7 when the neural tube closes and the brain separates into three parts, that the real fun begins.

Around week 5, your baby’s brain, spinal cord, and heart begin to develop. Your baby’s brain is part of the central nervous system, which also houses the spinal cord. There are three key components of a baby’s brain to consider. These include:

Cerebrum: Thinking, remembering, and feeling occurs in this part of the brain.
Cerebellum: This part of the brain is responsible for motor control, which allows the baby to move their arms and legs, among other things.
Brain stem: Keeping the body alive is the primary role of the brain stem. This includes breathing, heartbeat, and blood pressure.

The first trimester is a time of rapid development and separation of the various parts of the brain, according to Kecia Gaither, MD, MPH, double board certified in obstetrics and gynecology and maternal-fetal medicine, and director of perinatal services at NYC Health + Hospitals/Lincoln.

Within 4 weeks, the rudimentary structure known as the neural plate develops, which Gaither says is considered the precursor to the nervous system. “This plate elongates and folds on itself forming the neural tube — the cephalad portion of the tube becomes the brain, while the caudal portion elongates to eventually become the spinal cord,” she explains.

The neural tube continues to grow, but around week 6 or 7, Gaither says it closes, and the cephalad portion (aka the rudimentary brain) separates into three distinct parts: front brain, midbrain, and hindbrain.

It’s also during this time that neurons and synapses (connections) begin to develop in the spinal cord. These early connections allow the fetus to make its first movements.

During the second trimester, Gaither says the brain begins to take command of bodily functions. This includes specific movements that come from the hindbrain, and more specifically, the cerebellum.

One of the first notable developments, sucking and swallowing, are detectable around 16 weeks. Fast-forward to 21 weeks, and Gaither says baby can swallow amniotic fluid.

It’s also during the second trimester that breathing movements begin as directed by the developing central nervous system. Experts call this “practice breathing” since the brain (and more specifically, the brain stem) is directing the diaphragm and chest muscles to contract.

And don’t be surprised if you feel some kicking during this trimester. Remember the cerebellum or the part of the brain responsible for motor control? Well, its directing the baby’s movements, including kicking and stretching.

Gaither points out that a fetus can begin to hear during the late second trimester, and a sleep pattern emerges as the brainwaves from the developing hypothalamus become more mature.

By the end of the second trimester, Gaither says the fetal brain looks structurally much like the adult brain with the brain stem almost entirely developed.

The third trimester is full of rapid growth. In fact, as your baby continues to grow, so does the brain. “All the convoluted surfaces of the brain materialize, and the halves (right brain and left brain) will separate,” explains Gaither.

The most notable part of the brain during this final trimester is the cerebellum — hence, the kicking, punching, wiggling, stretching, and all of the other movements your baby is performing.

Share on PinterestIllustration by Alyssa Kiefer

While it may feel like you have control over nothing for the next 9 months, you do have a say in the foods you eat. Healthy brain development starts before pregnancy.

According to the Centers for Disease Control and Prevention, a healthy diet that includes folic acid, both from foods and dietary supplements, can promote a healthy nervous system.

“There are a number of defects along the baby’s brain and spinal cord that can occur when there is an abnormality occurring within the first weeks of brain development,” says Gaither. This may include anencephaly or spina bifida.

Gaither says two supplements in particular are involved with fetal brain development:

Folic acid

Folic acid (vitamin B9, specifically) supports fetal brain and spinal development. Not only does it play a role forming the neural tube, but Gaither says it’s also involved in the production of DNA and neurotransmitters, and it’s important for the production of energy and red blood cells.

Gaither recommends taking at least 400 to 600 micrograms of folic acid daily while you’re trying to conceive, and then continue with 400 micrograms daily during pregnancy.

“If you’ve had a child with a neural tube defect, then 4 grams daily in the preconceptual period is advised,” says Gaither.

Foods rich in folate/folic acid include dark green leafy vegetables, flaxseed, and whole grains.

Omega-3 fatty acids

Also important for fetal brain development are omega-3 fatty acids. “The brain has a high fat content, and the omegas are helpful in the deposition of the fat in not only the brain, but the eyes as well,” explains Gaither.

Omegas are also helpful in the neural synapse development or nerve connections to each other.

Foods rich in omega 3-fatty acids include salmon, walnuts, and avocados.

Fetal brain development starts before you may even realize you’re pregnant. That’s why it’s important to start on a prenatal vitamin that contains folic acid right away. If you’re not pregnant, but thinking about having a baby, add a prenatal vitamin to your daily routine.

The brain begins to form early in the first trimester and continues until you give birth. During pregnancy, fetal brain development will be responsible for certain actions like breathing, kicking, and the heartbeat.

Talk to your doctor if you have any questions about your pregnancy, fetal brain development, or how to nurture the baby’s developing brain.

When Does a Fetus Develop a Brain?

Your fetus will begin the process of developing a brain around week 5, but it isn’t until week 6 or 7 when the neural tube closes and the brain separates into three parts, that the real fun begins.

Cerebrum: Thinking, remembering, and feeling occurs in this part of the brain.
Cerebellum: This part of the brain is responsible for motor control, which allows the baby to move their arms and legs, among other things.
Brain stem: Keeping the body alive is the primary role of the brain stem. This includes breathing, heartbeat, and blood pressure.

It’s also during this time that neurons and synapses (connections) begin to develop in the spinal cord. These early connections allow the fetus to make its first movements.

During the second trimester, Gaither says the brain begins to take command of bodily functions. This includes specific movements that come from the hindbrain, and more specifically, the cerebellum.

One of the first notable developments, sucking and swallowing, are detectable around 16 weeks. Fast-forward to 21 weeks, and Gaither says baby can swallow amniotic fluid.

Gaither points out that a fetus can begin to hear during the late second trimester, and a sleep pattern emerges as the brainwaves from the developing hypothalamus become more mature.

By the end of the second trimester, Gaither says the fetal brain looks structurally much like the adult brain with the brain stem almost entirely developed.

The most notable part of the brain during this final trimester is the cerebellum — hence, the kicking, punching, wiggling, stretching, and all of the other movements your baby is performing.

Share on PinterestIllustration by Alyssa Kiefer

While it may feel like you have control over nothing for the next 9 months, you do have a say in the foods you eat. Healthy brain development starts before pregnancy.

According to the Centers for Disease Control and Prevention, a healthy diet that includes folic acid, both from foods and dietary supplements, can promote a healthy nervous system.

Gaither says two supplements in particular are involved with fetal brain development:

Folic acid

Gaither recommends taking at least 400 to 600 micrograms of folic acid daily while you’re trying to conceive, and then continue with 400 micrograms daily during pregnancy.

“If you’ve had a child with a neural tube defect, then 4 grams daily in the preconceptual period is advised,” says Gaither.

Foods rich in folate/folic acid include dark green leafy vegetables, flaxseed, and whole grains.

Omega-3 fatty acids

Omegas are also helpful in the neural synapse development or nerve connections to each other.

Foods rich in omega 3-fatty acids include salmon, walnuts, and avocados.

Talk to your doctor if you have any questions about your pregnancy, fetal brain development, or how to nurture the baby’s developing brain.

Development of the child's brain in the prenatal period

Author Olga Stepanova Reading 9 min Published 05/08/2022

The human nervous system develops from the outer germinal lobe - the ectoderm. From the same part of the embryo, in the process of development, sensory organs, skin and sections of the digestive system are formed. Already on the 17-18th day of intrauterine development (gestation), a layer of nerve cells is released in the structure of the embryo - the neural plate, from which subsequently, by the 27th day of gestation, the neural tube is formed - the anatomical precursor of the central nervous system. The process of neural tube formation is called neurulation. During this period, the edges of the neural plate gradually fold upward, connect, and fuse with each other (Figure 1). nine0005

Figure 1. Stages of formation of the neural tube (in section).

Viewed from above, this movement may be associated with zippering (Figure 2).

Figure 2. Stages of neural tube formation (top view).

One "zipper" is fastened from the center to the head end of the embryo (rostral wave of neurulation), the other - from the center to the tail end (caudal wave of neurulation). There is also a third "zipper", which ensures the fusion of the lower edges of the neural plate, which "zips" towards the head end and meets the first wave there. All these changes happen very quickly, in just 2 weeks. By the time neurulation is completed (31-32 days of gestation), not all women even know that they will have a child. nine0005

However, by this moment, the brain of the future person begins to form, the rudiment of two hemispheres appears. The hemispheres grow rapidly, and by the end of the 32nd day they make up ¼ of the entire brain! Then an attentive researcher will be able to see the rudiment of the cerebellum. During this period, the formation of the sense organs also begins.

Exposure to hazards during this period can lead to various malformations of the nervous system. One of the most common defects is a spinal hernia, which is formed as a result of improper “fastening” of the second “zipper” (impaired passage of the caudal wave of neurulation). Even erased, almost imperceptible variants of such spinal hernias sometimes reduce the child's quality of life, leading to various forms of incontinence (urinary and fecal incontinence). If a child has a problem such as enuresis (urinary incontinence) or encopresis (fecal incontinence), it is necessary to check if he has an erased form of spinal hernia. This can be found out by making an MRI of the child's lumbosacral spine. If a spinal hernia is detected, surgical treatment is indicated, which will lead to an improvement in pelvic functions. nine0005

In my practice there was a case of a 9-year-old boy who suffered from encopresis. Only on the 6th attempt was it possible to make a high-quality MRI image, which showed the presence of a spinal hernia. Unfortunately, up to this point, the child had already been observed by a psychiatrist and received appropriate treatment, since neurologists disowned him, believing that he had mental problems. A simple operation allowed the boy to return to a normal lifestyle, to fully control his pelvic functions. Even more revealing was the story of a 16-year-old who suffered from encopresis all his life. Neurologists sent him to gastroenterologists, gastroenterologists to psychiatrists. By the time we met, he had already received psychiatric treatment for ten (!!!) years. No one ever ordered him an MRI scan. Due to the fact that our recommendations for additional examination were carried out, the guy was diagnosed with serious disorders in the lumbar spine, which led to compression of the nerves and a violation of the sensitivity of the pelvic organs. Obviously, psychiatric treatment, as well as psychotherapy or other methods of psychological influence in all these cases, are completely useless and perhaps even harmful. nine0005

To prevent malformations such as spina bifida, pregnant women are advised to take folic acid early in pregnancy. Folic acid plays the role of a protector of the cells of the nervous system (neuroprotector), and with its regular intake, the effect of various harmful factors is significantly weakened.

In order to minimize the risk of malformations, the expectant mother must also avoid various adverse effects on the body. Such effects include taking sedatives containing phenobarbital (including Valocordin and Corvalol), hypoxia (oxygen starvation), overheating of the mother's body. Unfortunately, certain anticonvulsant drugs also lead to adverse effects. Therefore, if a woman forced to take such drugs plans to become pregnant, she should consult with her doctor. nine0005

Throughout the first half of pregnancy, new nerve cells (neurons) are born and develop very actively in the baby's future brain. First of all, the processes of generation of new nerve cells occur in the area surrounding the cerebral ventricles. Another area of the birth of new neurons is the hippocampus - the inner part of the cortex of the temporal regions of the right and left hemispheres. New nerve cells continue to appear after birth, but less intensively than in the prenatal period. Even in adults, young neurons have been found in the hippocampus. It is believed that this is one of the mechanisms due to which, if necessary, the human brain can plastically rebuild, restore damaged functions. nine0005

Newly born neurons do not stay in one place, but "crawl" to the places of their permanent "deployment" in the cortex and deep structures of the brain. This process begins towards the end of the second month of pregnancy and actively continues up to 26-29 weeks of intrauterine development. By the 35th week, the fetal cerebral cortex already has a structure inherent in the adult cortex.

Each neuron has processes through which it interacts with other cells of the body. nine0005

Figure 3. Neuron. The long process is the axon. Short branched processes - dendrites.

Neurons that have taken their place in the brain try to establish new relationships with other nerve cells, as well as with cells in other tissues of the body (for example, with muscle cells). The place where one cell connects to another is called a synapse. Such connections are very important, because it is thanks to them that the brain forms complex systems in which information can be quickly transmitted from one cell to another. Inside the cell, information is transmitted in the direction from the body to the end in the form of an electrical impulse. This impulse provokes the release of specific chemicals (neurotransmitters) into the synaptic cleft, which are stored at the end of the neuron, and through which information is transmitted from the neuron to the next cell. nine0005

Figure 4. Synapse

The first synapses were found in embryos at the age of 5 weeks of intrauterine development. The formation of synaptic contacts between neurons is most active starting from 18 weeks of intrauterine development. New connections between nerve cells are formed almost throughout life. During the period of active formation of synapses, the child's brain is subject to the negative influence of narcotic substances and certain medications that affect the exchange of neurotransmitters. These substances include, in particular, antipsychotics, tranquilizers and antidepressants - drugs that treat mental disorders. If the expectant mother is forced to take such drugs, she should consult with her doctor. And, of course, a pregnant woman should avoid the use of psychoactive substances if she is concerned about the mental development of her child. nine0005

Neurotransmitters are specific chemical compounds that transmit information in the nervous system.

A lot in human behavior depends on their correct exchange. Including, his mood, activity, attention, memory. There are factors that can affect their exchange. One such adverse effect is maternal smoking during pregnancy. The impact of nicotine generates several effects at once. The brain recognizes nicotine as an activating agent and begins to develop systems that are sensitive to it. Simply, the number of elements perceiving nicotine in the brain increases, the transmission of information through nicotine improves. At the same time, there is a negative impact on the exchange of those neurotransmitters that should be produced by the brain itself. First of all, this applies to those substances that are related to the provision of attention and the regulation of emotions. Studies have shown that maternal smoking during pregnancy increases the risk of having a child with attention deficit hyperactivity disorder (ADHD) by several times. The second consequence of intrauterine nicotine use after ADHD is oppositional defiant disorder, which is characterized by such manifestations as irritability, anger, constantly changing, often negative, mood, vindictiveness. Another effect of smoking is a deterioration in the condition of blood vessels, malnutrition of the fetus. Children of smoking mothers are born with low birth weight, and low birth weight itself is a risk factor for the development of subsequent behavioral problems. Due to vasospasm caused by exposure to nicotine, the fetal brain is prone to ischemic strokes - impaired blood supply to certain areas of the brain, their hypoxia, which has a very detrimental effect on all subsequent mental development [Nomura et al., 2010]. nine0005

One of the most important processes occurring in the developing brain of an unborn child is the covering of the long endings of nerve cells (axons) with myelin (myelination). A myelinated axon is shown in one of the previous drawings (a drawing of a neuron). Myelin is a substance that is somewhat like the insulation that covers wires. Thanks to him, the electrical signal moves from the body of the neuron to the end of the axon very quickly. The first signs of myelination are found in the brain of 20-week-old fetuses. This process is uneven. The axons that form the visual and motor nerve pathways, which are primarily useful to a newborn baby, are the first to be covered with myelin. A little later (almost before birth), the auditory pathways begin to become covered with myelin. nine0005

Cells of one of the brain tissues - neuroglia, which produce myelin, are very sensitive to lack of oxygen. Also, the myelination of the fetal brain can be affected by exposure to toxins, narcotic substances, a deficiency of the substances necessary for the brain from food (in particular, B vitamins, iron, copper and iodine), improper metabolism of certain hormones, such as thyroid hormones.

Alcohol is extremely harmful to the normal course of myelination processes. It interferes with myelination and, as a result, can cause severe mental development disorders, accompanied by mental retardation of the child. The impact of alcohol can also have a non-specific effect, leading to a variety of malformations. nine0005

About how intensively the brain of a child in the womb develops, at least the fact that in the period from 29 to 41 weeks, the brain increases almost 3 times! In many ways, this is due to myelination.

Relatively little is known about the mental development of a child in the prenatal period. At the same time, there are some interesting facts.

From 10 weeks of fetal development, babies suck their thumb (75% right). It turns out that future right-handers, for the most part, prefer to suck their right thumb, while future left-handers prefer their left [Hepper, 2013]. nine0005

When exposed to sound on the abdomen of pregnant women (37-41 weeks of pregnancy) through headphones, significant activation was found in the temporal areas in four and in the frontal areas in one fetus - the same areas of the cerebral cortex that will subsequently take part in the processing of speech information . This suggests that the child's brain is actively preparing to exist in the environment that is intended for him.

Embryogenesis of the brain

embryologydevelopmentbrain_brain

The brain is the most complex and perfect system of the human body. In its development, being the pinnacle of cellular organization, it goes through several difficult stages (development).

It should be noted that during the periods of laying the main elements of the brain, the fetus is the most vulnerable. Knowledge of teratogenic periods makes it possible to protect the fetus from pathological effects, therefore, it is more likely to get healthy offspring.

We also note that for a better understanding of the macro-processes of GM development, it is necessary to assimilate the micro-processes as well. nine0005

Actually, embryogenesis

So, at the gastrulation stage, as a result of complex morphogenetic changes, 3 germ layers are formed, one of which is the ectoderm - the source of the rudiments of the NS organs. Further, the neural plate is formed from the dorsal ectoderm, which is located along the midline of the back of the embryo.

Then the neural folds and n. groove. Of which, in turn, is the neural tube. In the early stages of embryogenesis, the neural tube is a multi-row neuroepithelium; later, 4 concentric zones differentiate in it. nine0005

Cells of the first, ventricular zone, are precursors of neurons and macroglia. The cells of the subventricular zone are devoid of nuclei and have a large proliferative potential. The intermediate / mantle / mantle zone is the source of the gray matter of the spinal cord and brain. And finally, the fourth, marginal or marginal zone of the neural tube - precedes the cerebral cortex, as well as the cerebellum.

Then the precursors of the cavities and divisions of the GM begin to form - the cerebral vesicles. In the fourth week of intrauterine development, the stage of three cerebral bubbles begins. nine0005

At this stage, the GM consists of three structures: forebrain (lat. Prosencephalon ), midbrain (lat. Mesencephalon ), posterior or rhomboid brain (lat. Rhombencephalon )

the stage of five cerebral vesicles, during which the forebrain is divided into the final (lat. Telencephalon ) and intermediate (lat. Diencephalon ) brain. And the rhomboid is subdivided into the back (lat. Metencephalon ) and the medulla oblongata (lat. Myelencephalon , hereinafter - Medulla oblongata ).

Later on, the following differentiate from the telencephalon: lateral ventricles of the brain, hemisphere of the brain, corpus callosum, fornix, septum pellucidum, and anterior commissure of the brain.

From the diencephalon are formed: the third ventricle, thalamus, epiphysis, geniculate body, hypothalamus.

From the midbrain develops: the aqueduct of Sylvius, the peduncle of the brain, the plate of the quadrigemina. nine0005

The fourth ventricle, pons and cerebellum are derived from the hindbrain.

Conclusion

The brain is a complex structure, so to speak. A structure consisting of several elements, the development of each of which is individual - and at the same time, inextricably linked with the rest of the elements.

The loss or underdevelopment of any part is almost always lethal for both the fetus and the already formed organism, because pathological changes in the brain lead to a chain of degenerative somatic changes throughout the body.